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Pregled bibliografske jedinice broj: 419782

Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study


Kaštelan, Darko; Grubić, Zorana; Kraljević, Ivana; Đurić, Koraljka; Kardum, Iva; Dušek, Tina; Štingl, Katarina; Giljević, Zlatko; Kerhin-Brkljačić, Vesna; Suchanek, Ernest; Koršić, Mirko
Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study // Journal of endocrinological investigation, 30 (2007), 6; 465-469 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 419782 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study

Autori
Kaštelan, Darko ; Grubić, Zorana ; Kraljević, Ivana ; Đurić, Koraljka ; Kardum, Iva ; Dušek, Tina ; Štingl, Katarina ; Giljević, Zlatko ; Kerhin-Brkljačić, Vesna ; Suchanek, Ernest ; Koršić, Mirko

Izvornik
Journal of endocrinological investigation (0391-4097) 30 (2007), 6; 465-469

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cyp19; Intron 4; Goos study; Genetics; peak bone mass; aromatase; Ttta polymorphism
(Cyp19; Intron 4; Goos Study; Genetics; peak bone mass; aromatase; Ttta polymorphism)

Sažetak
Finding that estrogen plays an important role in bone homeostasis in men prompted research on relationship of polymorphism at the CYP19 gene and the bone mass. Therefore, influence of 3-bp deletion/insertion polymorphism of CYP19 (TTTA)(7) allelle on the peak bone mass attainment in males was studied. Fifty-eight unrelated male participants, aged 21-35, were selected depending on the presence of (TTTA)(7) (no.=19) or (TTTA)(7- 3) (no.=39) alleles from the initial cohort of 92 young males. Heterozygotes (TTTA)(7)/(TTTA)(7-3) (no.=13) were not included in the analysis. Serum levels of estradiol, free testosterone, 25- hydroxy-vitamin D, bone alkaline phosphatase, osteocalcin, and beta-crosslaps were measured. Bone mass was measured by DXA at the hip and at the spine. (TTTA)(7-3) allele was associated with significantly lower femoral neck bone mineral density (BMD) (p=0.02). Logistic regression model indicated strong association of (TTTA)(7-3) allele with low BMD in the range of osteopenia/osteoporosis (p=0.014, odds ratio 12.36, confidence intervals 1.65-92.46). In the present study association of 3-bp deletion polymorphism of the (TTTA)(7) allele with decreased peak bone mass in males is reported for the first time. However, further studies are necessary to elucidate the functional relevance of this polymorphism

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
214-0000000-3354 - ISTRAŽIVANJA MIKROSATELITA UNUTAR REGIJE GLAVNOG SUSTAVA TKIVNE PODUDARNOSTI (Grubić, Zorana, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb


Citiraj ovu publikaciju

Kaštelan, Darko; Grubić, Zorana; Kraljević, Ivana; Đurić, Koraljka; Kardum, Iva; Dušek, Tina; Štingl, Katarina; Giljević, Zlatko; Kerhin-Brkljačić, Vesna; Suchanek, Ernest; Koršić, Mirko
Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study // Journal of endocrinological investigation, 30 (2007), 6; 465-469 (međunarodna recenzija, članak, znanstveni)
Kaštelan, D., Grubić, Z., Kraljević, I., Đurić, K., Kardum, I., Dušek, T., Štingl, K., Giljević, Z., Kerhin-Brkljačić, V., Suchanek, E. & Koršić, M. (2007) Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study. Journal of endocrinological investigation, 30 (6), 465-469.
@article{article, year = {2007}, pages = {465-469}, keywords = {Cyp19, Intron 4, Goos study, Genetics, peak bone mass, aromatase, Ttta polymorphism}, journal = {Journal of endocrinological investigation}, volume = {30}, number = {6}, issn = {0391-4097}, title = {Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study}, keyword = {Cyp19, Intron 4, Goos study, Genetics, peak bone mass, aromatase, Ttta polymorphism} }
@article{article, year = {2007}, pages = {465-469}, keywords = {Cyp19, Intron 4, Goos Study, Genetics, peak bone mass, aromatase, Ttta polymorphism}, journal = {Journal of endocrinological investigation}, volume = {30}, number = {6}, issn = {0391-4097}, title = {Decreased Peak Bone Mass is Associated with a 3-BP Deletion/Insertion of the Cyp19 Intron 4 Polymorphism : Preliminary Data from the Goos Study}, keyword = {Cyp19, Intron 4, Goos Study, Genetics, peak bone mass, aromatase, Ttta polymorphism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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