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Expression of oxalate transporters in rat renal proximal tubules is sex-dependent


Brzica, Hrvoje; Balen, Daniela; Breljak, Davorka; Sabolić, Ivan
Expression of oxalate transporters in rat renal proximal tubules is sex-dependent // Proceedings of the International Scientific Meeting of Anatomy and Physiology ; Fundamentals of Medicine / Mihelić, Damir ; Šimpraga, Miljenko ; Tkalčić, Suzana (ur.).
Zagreb: Medicinska naklada, Zagreb, 2009. str. 41-46 (predavanje, nije recenziran, cjeloviti rad (in extenso), znanstveni)


Naslov
Expression of oxalate transporters in rat renal proximal tubules is sex-dependent

Autori
Brzica, Hrvoje ; Balen, Daniela ; Breljak, Davorka ; Sabolić, Ivan

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the International Scientific Meeting of Anatomy and Physiology ; Fundamentals of Medicine / Mihelić, Damir ; Šimpraga, Miljenko ; Tkalčić, Suzana - Zagreb : Medicinska naklada, Zagreb, 2009, 41-46

ISBN
978-953-6062-72-0

Skup
The International Scientific Meeting of Anatomy and Physiology ; Fundamentals of Medicine

Mjesto i datum
Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska, 12-13. 06. 2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Anion transporters; gender differences; kidney; nephron; protein expression

Sažetak
In the mammalian proximal tubule, oxalate secretion is mediated by concerted action of sodium-independent sulphate transporter Sat1, localized in the cell basolateral membrane, and chloride/formate exchanger CFEX, localized in the cell brush-border membrane. Both transporters exhibit the male-dominant sex differences in their expression. A higher abundance of oxalate transporters in the male kidneys may contribute to formation and higher incidence of oxalate urolithiasis in male rats and humans, but the nature and extent of this contribution for each transporter is unknown.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
022-0222148-2146 - Bubrežni prijenosnici u sisavaca; spolne razlike i učinci toksičnih metala (Ivan Sabolić, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb