engleski

Sex-related expression of renal organic anion and cation transporters in different species

In the mammalian kidney, transport of endogenous and xenobiotic organic compounds is mediated by multispecific organic anion and cation transporters localized in the apical and basolateral cell membrane domains of the specific nephron segments. These transporters are also responsible for drug resistance, drug-drug interactions, and drug-induced nephrotoxicity. In rat and mouse proximal tubules, a number of these transporters exhibit sex differences in their expression. In comparison with those in rodents, in pig and human proximal tubules some transporters are absent, some exhibit different localization in the cell membrane domains, and none exhibits the sex-dependent expression. These differences indicate that: a) the data on renal transporters in one species can not simply be regarded as relevant for other species, and b) pigs may be better model then rodents for drug-related studies relevant to humans.

gender differences; human; kidney; mouse; organic compounds; pig; rat

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