engleski

Computer model for growth of single bacterial cell

Single cell models can mimic very closely the responses of living cell. Such models are convenient tools for testing the plausibility of basic biochemical mechanisms, for testing the potential in vivo compatibility of mechanisms postulated on the basis of in vitro enzymology and to make predictions of transient responses on changes of growth conditions. In this work a computer simulation of a mathematical model for growth of an individual bacterial cell was done which incorporated feedback control of nutrient uptake. This relatively simple model predicts changes of four chosen functional components of the cell. The system of differential equations was solved numerically in Matlab program using Runge - Kutta method. Results of simulation for various growth conditions were compared with experimental data from literature.

single cell model; bacterial growth simulation

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