engleski

Increased circulating adiponectin levels in type 1 diabetic patients and their impact on cardiovascular risk

Background: Adiponectin is considered to be responsible for endothelial protection and reduction of inflammation. The study was designed to assess the role of adiponectin in diabetes and determine parameters responsible for adiponectin modulation in patients with type 1 and type 2 diabetes, and the control group. Material and Methods: Adiponectin, high sensitive C-reactive protein, fibrinogen, homocysteine, C-peptide, and lipid panel in addition to clinical and laboratory parameters important for the definition of diabetes, obesity and the metabolic syndrome were measured in 80 patients included in the study. Results: ANOVA showed statistically significant among-group differences in adiponectin (p=0.028), body mass index (p<0.001), fasting blood glucose (p<0.001) and HDL-cholesterol (p=0.012) according to the type of diabetes. Significant between-group differences were also observed in adiponectin (p=0.033) and HDL-cholesterol (p=0.009) according to sex. Adiponectin correlated significantly (p<0.05) with body mass index, C-peptide, pulse pressure and HDL-cholesterol. After stepwise multivariate regression in type 1 diabetes for adiponectin, the best model (R2=0.989) included fibrinogen, leukocytes, uric acid and triglycerides. In type 2 diabetes the best model for adiponectin (R2=0.751) included C-peptide, leukocytes, systolic blood pressure, fasting blood glucose, HbA1c and HDL-cholesterol. Total ApN and HDL-C levels were significantly lower in men as compared to women. ApN was decreased in women &#61619; 50 years of age, but this was not the case in men. HDL-C decreased with age in women, and increased in men, but not significantly. Conclusion: In this study adiponectin levels were significantly higher in type 1 diabetes. Adiponectin could provide protection by affecting dyslipidemia and inflammation. The association between C-peptide and adiponectin is probably the reason for their different respective levels in different types of diabetes. Interrelations between adiponectin and inflammation, dyslipidemia, C-peptide levels and sex hormones, appear to be important for adiponectin modulation and action.

adiponectin; inflammation; dyslipidemia

nije evidentirano