engleski

Mathematical modeling of mixing in a horizontal rotating tubular bioreactor: "Simple flow" model

The construction of the horizontal rotating tubular bioreactor (HRTB) represents as a combination of a "thin-layer" bioreactor and a "biodisc" reactor. The bioreactor was made of a plastic tube whose interior was divided by the O-ring shaped partition walls. For the investigation of mixing properties in HRTB the temperature step method was applied. The temperature change in the bioreactor as a response to a temperature step in the inlet flow was monitored by six Pt-100 sensors (t90 response time 0.08 s and resolution 0.002 K) which were connected with interface unit and personal computer. Mixing properties of the bioreactor were modeled using the modified "tank in series" concept which divided the bioreactor into ideally mixed compartments. A mathematical mixing model with "simple flow" was developed according to the physical model of the compartments network and corresponding heat balances. Numerical integration of established set of differential equations was done by the Runge-Kutta-Fehlberg method. The final mathematical model with "simple flow" contained four adjustable parameters (N1, Ni, Fcr and Fp) and five fixed parameters.

horizontal rotating tubular bioreactor (HRTB); mixing;

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