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Pregled bibliografske jedinice broj: 416567

Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine


Kusačić Kuna, Sanja; Samardžić, Tatjana; Tešić, Vanja; Medvedec, Mario; Kuna, Krunoslav; Bračić, Irena; Despot, Marija; Dodig, Damir
Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine // Nuclear medicine communications, 30 (2009), 4; 263-269 doi:10.1097/MNM.0b013e3283299992 (međunarodna recenzija, članak, znanstveni)


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Naslov
Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine

Autori
Kusačić Kuna, Sanja ; Samardžić, Tatjana ; Tešić, Vanja ; Medvedec, Mario ; Kuna, Krunoslav ; Bračić, Irena ; Despot, Marija ; Dodig, Damir

Izvornik
Nuclear medicine communications (0143-3636) 30 (2009), 4; 263-269

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
I-131 activities ; remnant ablation ; thyroid cancer

Sažetak
The consensus about optimal activities of I-131 for thyroid remnant ablation has not yet been achieved. The aim of this study was to compare ablation rates obtained with different I-131 activities. The study included 466 patients divided into four groups according to I-131 activities given after total thyroidectomy for papillary thyroid cancer: group A (168 patients who received 888MBq/24 mCi), group B (125 patients who received 1480MBq/40 mCi), group C(65 patients who received 1850MBq/50 mCi), and group D(108 patients who received 4440MBq/120 mCi). Ablation outcome was assessed by whole- body scan in hypothyroid state 6– 9 months after ablation and finally 18– 21 months after the treatment. The rate of successful ablation was similar in the group of patients who received 24 and 40 mCi (75 and 71.2%, respectively). The higher rate of ablation was achieved in the groups treated with 50 and 120 mCi of radioiodine (87.69 and 90.74%, respectively). The ablation rates at the first follow-up examinations (59.5, 67.2, 73.9, 80.6%) were lower than at second control study (75.0, 71.2, 87.7, 90.7%) in all groups. Time required for thyroid remnant ablation seems to be >18 months. Our study indicates that activity of 50 mCi seems to be optimal to achieve a successful ablation rate (approximately 90%). Low I-131 activities are acceptable for lower risk patients because of satisfactory ablation rate (> 70%), lower expenses, and minimal radiation burden to patients as well as lower radiation exposure to clinical staff. The ablative use of high activities seems neither justified nor optimized.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
214-1080058-0488 - PROGNOSTIČKI POKAZATELJI BIOLOŠKOG PONAŠANJA KARCINOMA ŠTITNJAČE (Bence-Žigman, Zdenka, MZOS ) ( POIROT)

Ustanove:
Hrvatski zavod za javno zdravstvo,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb,
Sveučilište Libertas

Citiraj ovu publikaciju

Kusačić Kuna, Sanja; Samardžić, Tatjana; Tešić, Vanja; Medvedec, Mario; Kuna, Krunoslav; Bračić, Irena; Despot, Marija; Dodig, Damir
Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine // Nuclear medicine communications, 30 (2009), 4; 263-269 doi:10.1097/MNM.0b013e3283299992 (međunarodna recenzija, članak, znanstveni)
Kusačić Kuna, S., Samardžić, T., Tešić, V., Medvedec, M., Kuna, K., Bračić, I., Despot, M. & Dodig, D. (2009) Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine. Nuclear medicine communications, 30 (4), 263-269 doi:10.1097/MNM.0b013e3283299992.
@article{article, year = {2009}, pages = {263-269}, DOI = {10.1097/MNM.0b013e3283299992}, keywords = {I-131 activities, remnant ablation, thyroid cancer}, journal = {Nuclear medicine communications}, doi = {10.1097/MNM.0b013e3283299992}, volume = {30}, number = {4}, issn = {0143-3636}, title = {Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine}, keyword = {I-131 activities, remnant ablation, thyroid cancer} }
@article{article, year = {2009}, pages = {263-269}, DOI = {10.1097/MNM.0b013e3283299992}, keywords = {I-131 activities, remnant ablation, thyroid cancer}, journal = {Nuclear medicine communications}, doi = {10.1097/MNM.0b013e3283299992}, volume = {30}, number = {4}, issn = {0143-3636}, title = {Thyroid remnant ablation in patients with papillary cancer : a comparison of low, moderate and high activities of radioiodine}, keyword = {I-131 activities, remnant ablation, thyroid cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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