engleski

Attribute Selection Method

It is well known fact that proteins are grouped in families according to their structure, function and ancestry. Proteins that evolve from a common ancestor can have modified functionalities. So, we divide protein families into subfamilies according to the modified functionality. It is also well established hypothesis that certain amino acids at particular positions are "responsible" for the functional split within the same family. We call amino acids which are responsible for functional split SPECIFICITY DETERMINING RESIDUES or SDR's. So, the main task of our and other similar methods is determining SDR's.

Specificity Determining Residues; Multiple sequence alignment; log-likelihood ratio

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