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Inhibition of Ovarian Cancer Cell Metastasis by a Fusion Polypeptide Tat-ELP


Massodi, I.; Bidwell, G. L. III.; Davis, A.N.; Credit, K.; Flessner, M.; Raucher, Dražen
Inhibition of Ovarian Cancer Cell Metastasis by a Fusion Polypeptide Tat-ELP // Clinical & experimental metastasis, 26 (2009), 3; 251-260 doi:10.1007/s10585-009-9237-z (međunarodna recenzija, članak, znanstveni)


Naslov
Inhibition of Ovarian Cancer Cell Metastasis by a Fusion Polypeptide Tat-ELP

Autori
Massodi, I. ; Bidwell, G. L. III. ; Davis, A.N. ; Credit, K. ; Flessner, M. ; Raucher, Dražen

Izvornik
Clinical & experimental metastasis (0262-0898) 26 (2009), 3; 251-260

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Attachment - elastin-like polypeptide (ELP) - metastasis - SKOV-3 - Tat

Sažetak
Tumor cell metastasis is a complex, multi-step process that is a major cause of death and morbidity amongst cancer patients. Cell adhesion plays a critical role in the development of metastatic cancer, and it is mediated by interactions between receptors on the cell surface and ligands of the extracellular matrix or other surfaces. Therefore, inhibition of the cell adhesion process appears to be an effective method of preventing metastasis. This work describes a genetically engineered polypeptide with the potential to prevent cell adhesion and inhibit metastasis. We have found that the cell penetrating peptide Tat, fused with elastin-like polypeptide (ELP) inhibited adhesion, spreading, invasion and migration of SKOV-3 ovarian cancer cells in cell culture. Furthermore, we have also confirmed that Tat-ELP has anti-metastatic potential in an experimental ovarian cancer metastasis model in vivo, causing approximately 80% reduction in the tumor burden. Since cell attachment is an important step in tumor cell invasion and metastasis, these results suggest a novel role of Tat-ELP as a therapeutic intervention in cancer metastasis. Electronic supplementary material The online version of this article (doi:10.1007/s10585-009-9237-z) contains supplementary material, which is available to authorized users.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
219-0000000-3364 - Ciljano toplinsko dopremanje lijekova u solidne tumore (Dražen Raucher, )

Ustanove
Medicinski fakultet, Osijek

Profili:

Avatar Url Dražen Raucher (autor)

Citiraj ovu publikaciju

Massodi, I.; Bidwell, G. L. III.; Davis, A.N.; Credit, K.; Flessner, M.; Raucher, Dražen
Inhibition of Ovarian Cancer Cell Metastasis by a Fusion Polypeptide Tat-ELP // Clinical & experimental metastasis, 26 (2009), 3; 251-260 doi:10.1007/s10585-009-9237-z (međunarodna recenzija, članak, znanstveni)
Massodi, I., Bidwell, G., Davis, A., Credit, K., Flessner, M. & Raucher, D. (2009) Inhibition of Ovarian Cancer Cell Metastasis by a Fusion Polypeptide Tat-ELP. Clinical & experimental metastasis, 26 (3), 251-260 doi:10.1007/s10585-009-9237-z.
@article{article, year = {2009}, pages = {251-260}, DOI = {10.1007/s10585-009-9237-z}, keywords = {attachment - elastin-like polypeptide (ELP) - metastasis - SKOV-3 - Tat}, journal = {Clinical and experimental metastasis}, doi = {10.1007/s10585-009-9237-z}, volume = {26}, number = {3}, issn = {0262-0898}, title = {Inhibition of Ovarian Cancer Cell Metastasis by a Fusion Polypeptide Tat-ELP}, keyword = {attachment - elastin-like polypeptide (ELP) - metastasis - SKOV-3 - Tat} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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