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Maternal and Neonatal Effects of Substance Abuse during Pregnancy : Our Ten-year Experience


Vučinović, Mirjana; Roje, Damir; Vučinović, Zoran; Čapkun, Vesna; Bucat, Marija; Banović, Ivo
Maternal and Neonatal Effects of Substance Abuse during Pregnancy : Our Ten-year Experience // Yonsei medical journal, 49 (2008), 5; 705-713 doi:10.3349/ymj.2008.49.5.705 (međunarodna recenzija, članak, znanstveni)


Naslov
Maternal and Neonatal Effects of Substance Abuse during Pregnancy : Our Ten-year Experience

Autori
Vučinović, Mirjana ; Roje, Damir ; Vučinović, Zoran ; Čapkun, Vesna ; Bucat, Marija ; Banović, Ivo

Izvornik
Yonsei medical journal (0513-5796) 49 (2008), 5; 705-713

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Illicit drug; pregnancy outcome; neonatal outcome

Sažetak
Purpose The aim of the study was to assess perinatal outcome of pregnancy burdened with maternal addiction in comparison with an unselected population from a European transition country. Materials and Methods Data on pregnancies complicated by illicit drug abuse (n = 85) managed during a 10-year period (1997 - 2007) at Split University Hospital were analyzed. Data on the type of drug, course of gestation and labor, and on perinatal outcome were considered. Data on all non-dependence pregnancies recorded during the study period were used as a control group. Results During the study period, there were 85 dependence-complicated pregnancies (0.2%). Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%). Premature delivery was significantly more common in the group of pregnant addicts (21% vs. 6%) ; 49% of pregnant addicts were carriers of hepatitis C virus (HCV) and 14% of hepatitis B virus (HBV). Neonatal abstinence syndrome developed in 61 infants (7%) born to addicted mothers. There were 4 cases (4.6%) of early neonatal death ; 7 neonates had 5-minute Apgar score ≤ 7 (8%) ; 29 neonates had low birth weight for age (33%) ; and 7 neonates had congenital anomalies (8%). The risk of various congenital anomalies was 3-fold in the group of children born to addicted mothers. Conclusion Addiction pregnancies present a small but high-risk group according to perinatal outcome. Appropriate obstetric and neonatal care can reduce the rate of complications in these pregnancies and improve perinatal outcome.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-0000000-0533 - Uloga apoptoze u posteljici kod intrauterinog zastoja rasta i preeklampsije (Ivana Kuzmić Prusac, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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