engleski

Soluble interleukin-6 receptor (sIL-6R) levels in the cerebrospinal fluid and serum of patients with multiple sclerosis.

Interleukin-6 (IL-6) is a proinflammatory cytokine which mediates cellular responses during inflammation and immune activation. Elevated levels of IL-6 are found in multiple sclerosis (MS) lesions and cerebrospinal fluid (CSF). This cytokine acts through IL-6 receptors. Soluble forms of these receptors are released from the cell surface and can be detected in CSF and serum. The aim of this study was to measure CSF and serum levels of sIL-6R (gp80) in patients with relapsing-remitting MS during exacerbations. We studied 20 patients with relapsing-remitting MS and 19 patients with non-inflammatory neurological diseases (NIND). In MS patients CSF and serum samples were obtained during exacerbations of the disease. Soluble IL-6R (gp80) in CSF and serum was measured by ELISA method, and values (median) were expressed in pg/mL. Low levels of sIL-6R were detected in the CSF of MS (950) and NIND (975) patients and were not significantly different. Serum sIL-6R levels were approximately 25-40 times higher than CSF levels in MS (28750) and NIND (35250) patients and were not significantly different. We found no significant difference in levels of sIL-6R in the CSF and serum between MS and NIND patients. Therefore, analysis of sIL-6R in the CSF and serum of relapsing-remitting MS patients is of limited value as a marker of disease activity.

interleukin-6 receptor; multiple screrosis; cerebrospinal fluid; human serum

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