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Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice (CROSBI ID 86684)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Peričić, Danka ; Jazvinšćak, Maja ; Švob, Dubravka ; Mirković, Kety Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice // Pharmacology, biochemistry and behavior, 67 (2000), 3; 507-510-x

Podaci o odgovornosti

Peričić, Danka ; Jazvinšćak, Maja ; Švob, Dubravka ; Mirković, Kety

engleski

Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice

To explore the possible involvement of beta adrenoceptor antagonists in the previously observed anticonvulsive effect of swim stress, the mice were, prior to administration of convulsants, pre-treated with propranolol (a non-selective beta adrenoceptor antagonist), betaxolol (a selective beta-1 adrenoreceptor antagonist), or ICI 118, 551 (a selective beta-2 adrenoreceptor antagonist). In control unstressed animals only propranolol (10 mg/kg i.p.) produced a significant change. It enhanced the threshold dose of picrotoxin producing tonic hindlimb extension. However, in swim stressed animals propranolol enhanced doses of picrotoxin producing tonic hindlimb extension and death, while betaxolol (20 mg/kg i.p.) enhanced doses of picrotoxin producing running/bouncing clonus, tonic hindlimb extension and death. Pre-treatment with ICI 118, 551 (4 mg/kg i.p.) failed to affect doses of picrotoxin producing convulsions and death. The results demonstrate that blockade of beta-1 adrenoceptors potentiates the anticonvulsant effect of swim stress against convulsions produced by picrotoxin, a noncompetitive GABAA receptor antagonist.

swim stress; convulsions; mice; picrotoxin; propranolol; betaxolol; ICI 118; 551

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Podaci o izdanju

67 (3)

2000.

507-510-x

objavljeno

0091-3057

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost