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Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding


Tomić, Sanja; Nillson, Lennart; Wade, Rebecca
Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding // Molecular Modeling and Prediction of Bioactivity / Gudertofte, K ; Jorgensen, F. S. (ur.).
New York: Kluwer Academic/Plenum Publishers, 2000. str. 269-270


Naslov
Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding

Autori
Tomić, Sanja ; Nillson, Lennart ; Wade, Rebecca

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Molecular Modeling and Prediction of Bioactivity

Urednik/ci
Gudertofte, K ; Jorgensen, F. S.

Izdavač
Kluwer Academic/Plenum Publishers

Grad
New York

Godina
2000

Raspon stranica
269-270

ISBN
0-306-46217-6

Ključne riječi
Quantitative Structure-Activity Relationship (QSAR), COMBINE analysis, molecular modeling, gene regulation, molecular mechanics

Sažetak
To identify the major determinants of the DNA binding specificity of nuclear transcription factors, the Comparative Binding Energy (COMBINE) analysis has been performed. 3DQSAR models were derived for a set of 320 complexes of DNA and glucocorticoid receptor mutants, and the parameters important for determining binding specificity were identified.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
00980608

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Sanja Tomić, (113604)