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Pregled bibliografske jedinice broj: 410024

Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients with Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome


Marić, Andreja; Katalinić, Darko; Sobočan, Nikola; Vrkljan, Milan; Solter, Miljenko; Zjačić-Rotkvić, Vanja
Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients with Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome // Endocrinologist, 18 (2008), 226-229 (međunarodna recenzija, članak, znanstveni)


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Naslov
Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients with Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome
(Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients With Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome)

Autori
Marić, Andreja ; Katalinić, Darko ; Sobočan, Nikola ; Vrkljan, Milan ; Solter, Miljenko ; Zjačić-Rotkvić, Vanja

Izvornik
Endocrinologist (1051-2144) 18 (2008); 226-229

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bilateral pheochromocytoma; men 2a syndrome; laparoscopic adrenalectomy; octreotide treatment

Sažetak
Pheochromocytoma, a rare tumor arising from catecholamine-producing chromaffin cells in the adrenal medulla, can appear sporadically or be a part of a tumor syndrome, including multiple endocrine neoplasia type 2 (MEN 2). MEN 2 is a rare disorder characterized by the presence of medullary thyroid carcinoma (MTC) with pheochromocytoma and/or primary hyperparathyroidism. Clinical presentation requires biochemical confirmation of catecholamine oversecretion, followed by anatomic localization methods (computed tomography, magnetic resonance) and functional diagnostic procedures (metaiodobenzylguanidine scintigraphy, In-111-labeled octreotide), allowing the possibilities for radiotherapy in some cases. Laparoscopic adrenalectomy is the standard treatment for benign pheochromocytoma, including the bilateral forms. We present a case of a 35-year-old woman patient with a history of MTC and giant bilateral pheochromocytomas (left adrenal tumor: 11 × 9 cm, right adrenal tumor: 4 × 3 cm in size on magnetic resonance, respectively). She had multiple endocrine neoplasia type 2A confirmed by genetic testing. Because of religious reasons, patient refused surgical treatment. In-111-labeled scintigraphy was performed, which suggested the use of subcutaneous octreotide as an alternative to surgical therapy. We report 24 months of successful treatment with octreotide, which improved symptoms, decreased hormone secretion, and slightly induced a reduction in size of the tumor. Our case shows that an octreotide treatment of pheochromocytoma can be an acceptable alternative to surgery when operation is not possible.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
177873
108-1080058-0047 - Molekularni biljezi u solidnim tumorima - prediktivni i prognostički značaj (Pleština, Stjepko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Marić, Andreja; Katalinić, Darko; Sobočan, Nikola; Vrkljan, Milan; Solter, Miljenko; Zjačić-Rotkvić, Vanja
Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients with Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome // Endocrinologist, 18 (2008), 226-229 (međunarodna recenzija, članak, znanstveni)
Marić, A., Katalinić, D., Sobočan, N., Vrkljan, M., Solter, M. & Zjačić-Rotkvić, V. (2008) Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients with Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome. Endocrinologist, 18, 226-229.
@article{article, year = {2008}, pages = {226-229}, keywords = {bilateral pheochromocytoma, men 2a syndrome, laparoscopic adrenalectomy, octreotide treatment}, journal = {Endocrinologist}, volume = {18}, issn = {1051-2144}, title = {Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients with Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome}, keyword = {bilateral pheochromocytoma, men 2a syndrome, laparoscopic adrenalectomy, octreotide treatment} }
@article{article, year = {2008}, pages = {226-229}, keywords = {bilateral pheochromocytoma, men 2a syndrome, laparoscopic adrenalectomy, octreotide treatment}, journal = {Endocrinologist}, volume = {18}, issn = {1051-2144}, title = {Long-Term Octreotide Treatment is an Alternative to Adrenalectomy in Patients With Bilateral Pheochromocytoma in the Multiple Endocrine Neoplasia Type 2A Syndrome}, keyword = {bilateral pheochromocytoma, men 2a syndrome, laparoscopic adrenalectomy, octreotide treatment} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • MEDLINE





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