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Pregled bibliografske jedinice broj: 409850

Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients.


Bronić, Ana; Ferenčak, Goran; Zadro, Renata; Stavljenić Rukavina, Ana; Bernat, Robert
Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients. // Molecular biology reports, 36 (2009), 1; 1-5 doi:10.1007/s11033-007-9144-9 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 409850 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients.

Autori
Bronić, Ana ; Ferenčak, Goran ; Zadro, Renata ; Stavljenić Rukavina, Ana ; Bernat, Robert

Izvornik
Molecular biology reports (0301-4851) 36 (2009), 1; 1-5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
factor XIII ; thrombosis

Sažetak
Arterial thrombosis is the major reason for severe complications of coronary artery disease (CAD). Recently it has been suggested that the FXIII-A Val34Leu polymorphism, affecting clot stability, provides protection against thrombosis. Results published up to date implicate that there is a significant correlation between geographical area and the Leu34 allele prevalence and that its contribution to arterial thrombosis is different in different populations. The purpose of this study was to determine frequency of Leu34 allele in Croatian subjects as well as to estimate its association with a CAD. FXIII-A Val34Leu genotyping was carried out by real- time PCR method on the LightCycler using melting curve analysis with forward 5'- AACTTCCAGGACCGGCTTT-3' and reverse 5'- ACCCAGAGTGGTGGGGAA-3' primers. The Leu34 allele frequency in studied Croatian subjects was 24.3%. No significant differences were found in the prevalence of FXIII-A Val34Leu genotype or Leu34 allele distribution between studied subjects (P > 0.05). Carriage of the Leu34 allele was not significantly associated with CAD or MI risk reduction (P > 0.05). This is the first report that studies the prevalence of the Leu34 allele frequency in Croatian subjects and our results suggest that possession of the Leu 34 alele does not provide protection against MI

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080316-0298 - Molekularna osnova aterogeneze

Ustanove:
Medicinski fakultet, Zagreb,
Sveučilište Libertas

Profili:

Avatar Url Renata Zadro (autor)

Avatar Url Ana Bronić (autor)

Avatar Url Robert Bernat (autor)

Avatar Url Goran Ferenčak (autor)

Avatar Url Ana Stavljenić (autor)

Citiraj ovu publikaciju

Bronić, Ana; Ferenčak, Goran; Zadro, Renata; Stavljenić Rukavina, Ana; Bernat, Robert
Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients. // Molecular biology reports, 36 (2009), 1; 1-5 doi:10.1007/s11033-007-9144-9 (međunarodna recenzija, članak, znanstveni)
Bronić, A., Ferenčak, G., Zadro, R., Stavljenić Rukavina, A. & Bernat, R. (2009) Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients.. Molecular biology reports, 36 (1), 1-5 doi:10.1007/s11033-007-9144-9.
@article{article, year = {2009}, pages = {1-5}, DOI = {10.1007/s11033-007-9144-9}, keywords = {factor XIII, thrombosis}, journal = {Molecular biology reports}, doi = {10.1007/s11033-007-9144-9}, volume = {36}, number = {1}, issn = {0301-4851}, title = {Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients.}, keyword = {factor XIII, thrombosis} }
@article{article, year = {2009}, pages = {1-5}, DOI = {10.1007/s11033-007-9144-9}, keywords = {factor XIII, thrombosis}, journal = {Molecular biology reports}, doi = {10.1007/s11033-007-9144-9}, volume = {36}, number = {1}, issn = {0301-4851}, title = {Impact of FXIII-A Val34Leu polymorphism on coronary artery disease in Croatian patients.}, keyword = {factor XIII, thrombosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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