engleski

Sex chromosome abnormalities in asoospermic males

Cytogenetical analysis has been carried out on 32 patiens diagnosed with azoospermia or hypogonadism. Conventional cytogenetical G - banding method and Flurescent in situ hybridization technique were considered in cultured peripheral blood. 22 cases showed karyotypes pure 47, XXY - Klinefelter syndrome, 2 cases 47, XXY/46, XY - mosaic Klinefelter sy., 1 case 47, XXY/48, XXXY, 2 cases 48, XXY, + mar, 3 cases 46, XX male, 1 case 47, XYY, 1 case 45, X, psu dic(Y, 13). FISH identified two marker chromosomes, detected SRY gene translocation on X chromosome in cases with karyotyp 46, XX male, also in karyotyp 45, X, psu dic Y, 13. Cytogenetical research is very important to detect the cause of male infertility.

Cytogenetical analysis; Sex chromosome abnormalities

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