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Pregled bibliografske jedinice broj: 409518

Abrupt Telomere Shortening in normal human fibroblasts


Škrobot Vidaček, Nikolina; Ćukušić, Andrea; Ivanković, Milena; Fulgosi, Hrvoje; Huzak, Miljenko; Smith, James R.; Rubelj, Ivica
Abrupt Telomere Shortening in normal human fibroblasts // Experimental gerontology, 45 (2010), 3; 235-242 doi:10.1016/j.exger.2010.01.009 (međunarodna recenzija, članak, znanstveni)


Naslov
Abrupt Telomere Shortening in normal human fibroblasts

Autori
Škrobot Vidaček, Nikolina ; Ćukušić, Andrea ; Ivanković, Milena ; Fulgosi, Hrvoje ; Huzak, Miljenko ; Smith, James R. ; Rubelj, Ivica

Izvornik
Experimental gerontology (0531-5565) 45 (2010), 3; 235-242

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Telomeres ; cell senescence ; aging ; telomere shortening ; human fibroblasts

Sažetak
Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell senescence is of great interest for biology and medicine. Several discoveries strongly support telomere shortening as the main molecular mechanism that limits the growth of normal cells. Although cultures gradually approach their growth limit, appearance of individual senescent cells is sudden and stochastic. A theoretical model of abrupt telomere shortening has been proposed in order to explain this phenomenon, but until now there was no reliable experimental evidence in support of this idea. Here, we present evidence for the generation of extrachromosomal circular telomeric DNA as a result of abrupt telomere shortening in normal human fibroblasts. This mechanism ensures heterogeneity in growth potential among individual cells, which is crucial for gradual progression of aging process.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2768 - Struktura i funkcija telomera u kontroli staničnog rasta (Ivica Rubelj, )

Ustanove
Prirodoslovno-matematički fakultet, Matematički odjel, Zagreb,
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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