engleski

Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity

Human obesity is a multifactorial syndrome influenced by both environmental and genetic factors. We explored the association of genetic polymorphisms of: estrogen receptor alpha (ESR1-TA repeats) ; interleukin-6 (IL-6 G-174C) ; apolipoprotein E (APO e2, e3, e4) ; lipoprotein lipase Pvu II (LPL P+/-) with clinical variables: gender, age, body mass index (BMI), diet type and biological variables: triglycerides, cholesterol, HDL, LDL, CRP, homocysteine, urate, and glucose in 105 healthy young subjects (20-35 yrs) of Croatian origin. ESR1, LPL and APO E genetic polymorphic variants could represent predictive genetic risk markers for obesity-related metabolic disorders in young healthy subjects. Mediterranean type of diet is also an important positive factor in abdominal obesity.

ESR1 ; APOE ; LPL ; IL-6 gene variants ; young healthy subjects ; obesity

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