engleski

Polyploidy in early spontaneous abortions

Polyploidy is a condition in which there is more than two sets of chromosomes. A total of 321 cases of first trimester spontaneous abortions between 4 and 13 weeks of gestation were analyzed cytogenetically by direct - preparation method using chorionic villi. Among 54% of abnormal karyotypes, trisomy was predominant. The second most common abnormality was triploidy found in 25 (7, 8%) cases. Triploidy may arise from fertilization of haploid egg by two haploid sperm or by maternal or paternal meiotic errors. Tetrapoidy is a rare ploidy abnormality and was detected in 3 (0, 9%) cases, 92, XXYY and 92, XXXX sex chromosome complement. Among the triploid abortions the gonosomal constitution of XXY prevailed (14 cases), followed by XXX (8cases) and XYY (3 cases). The maternal age ranged from 18 to 35 age and the gestational age from 6 to 13 weeks. In this study the frequency of poliploidy abortions decreased with maternal age, what confirms that increased maternal age is not a risk factor and mechanism of poliploidy. Triploidy and tetraploidy together account for 18% of chromosomal abnormalities and give rise to a significant proportion of human pregnancy wastage. Poliploidyies are numerical abnormalities, are sporadic, and they do not usually recur in subsequent pregnancies.

Poliploidy; spontaneous abortions

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