Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 409308

A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1


Popović, Marta; Žaja, Roko; Lončar, Jovica; Smital, Tvrtko
A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1 // Marine environmental research, 69 (2010), S1; S11-S13 doi:10.1016/j.marenvres.2009.10.016 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 409308 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1

Autori
Popović, Marta ; Žaja, Roko ; Lončar, Jovica ; Smital, Tvrtko

Izvornik
Marine environmental research (0141-1136) 69 (2010), S1; S11-S13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Abch subfamily ; zebrafish ; phylogeny ; membrane topology ; tissue distribution

Sažetak
Abch1 is a novel ABC transporter found in fish lineage. The aim of this study was to characterise zebrafish Abch1 using phylogenetic analysis, membrane topology prediction and tissue expression pattern determined by qRT-PCR. Phylogenetic analysis confirmed that no Abch1 orthologs can be found in other vertebrates, but similar genes have been found in invertebrate species. Abch1 is most closely related to the ABCG subfamily, although it shares only 12-14% of amino acid sequence identity with ABCG subfamily members. Topology analysis indicated that Abch1 is a half transporter that consists of six transmembrane domains with reverse domain arrangement (TMD-ABC), like ABCG subfamily members, but with differences in loop organization. Tissue distribution pattern revealed the highest Abch1 expression in brain and gill, followed by lower expression in gut, gonads and liver. Taken together, we hypothesise that fish Abch1 may be either involved in sterol transport similar to ABCG1, or is a part of the MXR defence like ABCG2. These questions remain to be addressed in further research.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
Rad je prezentiran na skupu Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15), održanom od 17.-20.05.2009., Bordeaux, Francuska.



POVEZANOST RADA


Projekt / tema
4877 - Ekotoksikološko značenje ABC transportnih proteina u vodenih organizama (Tvrtko Smital, MZOS)

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marta Popović (autor)

Avatar Url Tvrtko Smital (autor)

Avatar Url Roko Žaja (autor)

Avatar Url Jovica Lončar (autor)

Citiraj ovu publikaciju

Popović, Marta; Žaja, Roko; Lončar, Jovica; Smital, Tvrtko
A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1 // Marine environmental research, 69 (2010), S1; S11-S13 doi:10.1016/j.marenvres.2009.10.016 (međunarodna recenzija, članak, znanstveni)
Popović, M., Žaja, R., Lončar, J. & Smital, T. (2010) A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1. Marine environmental research, 69 (S1), S11-S13 doi:10.1016/j.marenvres.2009.10.016.
@article{article, year = {2010}, pages = {S11-S13}, DOI = {10.1016/j.marenvres.2009.10.016}, keywords = {Abch subfamily, zebrafish, phylogeny, membrane topology, tissue distribution}, journal = {Marine environmental research}, doi = {10.1016/j.marenvres.2009.10.016}, volume = {69}, number = {S1}, issn = {0141-1136}, title = {A novel ABC transporter: the first insight into zebrafish (Danio rerio) Abch1}, keyword = {Abch subfamily, zebrafish, phylogeny, membrane topology, tissue distribution} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font