engleski

Mannose 6-phosphate/insulin-like growth factor 2 receptor in carcinogenesis

The cation independent mannose 6-phosphate/insulin-like growth factor 2 (M6P/IGF2R) is a multifunctional receptor. It is included in a variety of cellular processes which become disregulated in cancer. Its tumor suppressor role was recognized a long time ago. However, due to its multifunctionality, it is not easy to understand the extent of its relevance to normal cellular physiology. Accordingly, it is even more difficult understanding its role in carcinogenesis. This review presents critical and focused highlights of data relating to M6P/IGF2R, obtained during more than 25 years of cancer research.

mannose 6-phosphate/insulin-like growth factor 2 receptor ; LOH ; mutation ; cancer

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