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Pregled bibliografske jedinice broj: 409157

Stable and unstable chromosome aberrations measured after occupational exposure to ionizing radiation and ultrasound


Fučić, Aleksandra; Želježić, Davor; Kašuba, Vilena; Kopjar, Nevenka; Rozgaj, Ružica; Lasan, Ružica; Mijić, August; Hitrec, Vlasta; Lucas, Joe Nathan
Stable and unstable chromosome aberrations measured after occupational exposure to ionizing radiation and ultrasound // Croatian medical journal, 48 (2007), 3; 371-377 (međunarodna recenzija, članak, znanstveni)


Naslov
Stable and unstable chromosome aberrations measured after occupational exposure to ionizing radiation and ultrasound

Autori
Fučić, Aleksandra ; Želježić, Davor ; Kašuba, Vilena ; Kopjar, Nevenka ; Rozgaj, Ružica ; Lasan, Ružica ; Mijić, August ; Hitrec, Vlasta ; Lucas, Joe Nathan

Izvornik
Croatian medical journal (0353-9504) 48 (2007), 3; 371-377

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chromosome aberrations; ultrasound

Sažetak
To evaluate chromosome aberration and fluorescent in situ hybridization (FISH) assays as a method to estimate of health risk, we monitored 9 male subjects occupationally exposed to low doses of both ionizing radiation and ultrasound during a period of over 3 years. Sampling was performed at 6-month intervals during a three-year period. First we used conventional chromosomal aberrations analysis. When the aberration frequency for a particular subject reached the background, we measured translocations in the final sample, using fluorescence in situ hybridization. Chromosome painting probes for chromosomes 1, 2, and 4 were used simultaneously. Dicentric and ring chromosomes were eliminated within a year. Translocations persisted and deviated from control values in all examinees. Translocations were detected long after unstable aberrations decreased to the background level. Fluorescence in situ hybridization-based translocation detection was a reliable method for monitoring chronic occupational clastogen exposure. Chromosome aberration assay correlated with translocation frequency. Stable chromosomal aberrations reflected cumulative genome damage during job exposure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
108-0000000-0353 - Novi pristupi dijagnostici nasljednih bolesti (Davor Begović, )
108-1080399-0335 - Eksperimentalni embrionalni tumori i razvoj zametaka sisavaca in vitro i in vivo (Florijana Jakuš, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE