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Pregled bibliografske jedinice broj: 408312

Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat


Vukšić, Tihomir; Zoričić, Ivan; Brčić, Luka; Sever, Marko; Kliček, Robert; Radić, Božo; Cesarec, Vedran; Berkopić, Lidija; Keller, Neike; Boban Blagaić, Alenka et al.
Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat // Surgery Today, 37 (2007), 9; 768-777 doi:10.1007/s00595-006-3498-9 (međunarodna recenzija, članak, znanstveni)


Naslov
Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat

Autori
Vukšić, Tihomir ; Zoričić, Ivan ; Brčić, Luka ; Sever, Marko ; Kliček, Robert ; Radić, Božo ; Cesarec, Vedran ; Berkopić, Lidija ; Keller, Neike ; Boban Blagaić, Alenka ; Kokić, Neven ; Jelić, Ivan ; Geber, Juraj ; Anić, Tomislav ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Surgery Today (0941-1291) 37 (2007), 9; 768-777

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pentadecapeptide BPC 157; Ileoileal anastomosis healing; Rat

Sažetak
Purpose Gastric pentadecapeptide BPC 157 (BPC 157), which has been shown to be safe in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia), may be able to cure intestinal anastomosis dehiscence. This antiulcer peptide shows no toxicity, is limit test negative, and a lethal dose is not achieved. It is stable in human gastric juice. In comparison with other standard treatments it is more effective for ulcers and various wounds, and can be used without a carrier needed for other peptides, both locally and systemically (i.e., perorally, parenterally). We studied the effectiveness of BPC 157 for ileoileal anastomosis healing in rats. Methods We assessed ileoileal anastomosis dehiscence macroscopically, histologically, and biomechanically (volume [ml] infused through a syringe-perfusion pump system (1  ml/10  s), and pressure [mmHg] to leak induction [catheter connected to a chamber and a monitor, at 10  cm proximal to anastomosis]), at 1, 2, 3, 4, 5, 6, 7, and 14 days. BPC 157 (10  µ ; g, 10  ng, 10  pg/kg i.p. (or saline [5  ml/kg]) was first administered after surgery, while it was last given 24  h before either assessment or sacrifice. Results Throughout the experiment, both higher doses of BPC 157 were shown to improve all parameters of anastomotic wound healing. The formation of adhesions remained slight, the blood vessels were filled with blood, and a mild intestinal passage obstruction was only temporarily observed. Anastomosis without leakage induces markedly higher volume and pressure values, with a continuous increase toward healthy values. From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization. Conclusion This study showed BPC 157 to have a beneficial effect on ileoileal anastomosis healing in the rat.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1080321-0389 - Utjecaj pentadekapeptida BPC 157 na ženski urogenitalni sustav (Hrvoje Vrčić, )
108-1083570-3611 - Pentadekapeptid BPC 157- učinkovita terapija ozljeda mišića i tetive (Božidar Šebečić, )
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3636 - Učinak BPC 157 na induciranu bilijarnu opstrukciju (Tomislav Anić, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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