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Pregled bibliografske jedinice broj: 408176

The function of Noto in the tail bud development


Mitrečić Žižić, Marica; Mitrečić, Dinko; Pochet, Roland; Kostović-Knežević, Ljiljana; Gajović, Srećko
The function of Noto in the tail bud development // Cells tissues organs (2009) (znanstveni, poslan)


CROSBI ID: 408176 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The function of Noto in the tail bud development

Autori
Mitrečić Žižić, Marica ; Mitrečić, Dinko ; Pochet, Roland ; Kostović-Knežević, Ljiljana ; Gajović, Srećko

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Cells tissues organs (2009)

Status rada
Poslan

Ključne riječi
Noto; notochord; tail bud; embryo; mouse

Sažetak
Noto is a transcription factor expressed in the notochord and involved in its development. Noto mouse mutants exhibit segmental lack of the notochord in the caudal part of the embryo, and subsequent tail truncation in the adult animals. In order to address the relationship between the tail bud (the undifferentiated mesenchymal cells in the tip of the embryo tail) and the caudal notochord, NotoGFP loss of function mutants were analyzed. Taking advantage of the NotoGFP heterozygotes we could track Noto expressing cells from the tail bud, over the tail cord, to the caudal notochord, and confirm a morphological continuum from the tail bud mesenchyme to the caudal notochord. Loss of Noto disturbed the tail bud differentiation: Noto expressing cells were scattered in the tail bud mesenchyme and instead to the tail cord they segregated in the notochord- like structure within the medullary cord, which subsequently disappeared. In the tail cord, instead of the notochord, additional lumen of the tail gut was formed. These findings suggest that Noto is involved in both rearrangement and differentiation of the tail bud cells during notochord formation.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
108-1081870-1902 - Uloga gena u diferencijaciji i plastičnosti središnjeg živčanog sustava miša (Gajović, Srećko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Mitrečić Žižić, Marica; Mitrečić, Dinko; Pochet, Roland; Kostović-Knežević, Ljiljana; Gajović, Srećko
The function of Noto in the tail bud development // Cells tissues organs (2009) (znanstveni, poslan)
Mitrečić Žižić, M., Mitrečić, D., Pochet, R., Kostović-Knežević, L. & Gajović, S. (2009) The function of Noto in the tail bud development. Poslan u Cells tissues organs. [Preprint].
@unknown{unknown, author = {Mitre\v{c}i\'{c} \v{Z}i\v{z}i\'{c}, Marica and Mitre\v{c}i\'{c}, Dinko and Pochet, Roland and Kostovi\'{c}-Kne\v{z}evi\'{c}, Ljiljana and Gajovi\'{c}, Sre\'{c}ko}, year = {2009}, keywords = {Noto, notochord, tail bud, embryo, mouse}, journal = {Cells tissues organs}, title = {The function of Noto in the tail bud development}, keyword = {Noto, notochord, tail bud, embryo, mouse} }
@unknown{unknown, author = {Mitre\v{c}i\'{c} \v{Z}i\v{z}i\'{c}, Marica and Mitre\v{c}i\'{c}, Dinko and Pochet, Roland and Kostovi\'{c}-Kne\v{z}evi\'{c}, Ljiljana and Gajovi\'{c}, Sre\'{c}ko}, year = {2009}, keywords = {Noto, notochord, tail bud, embryo, mouse}, journal = {Cells tissues organs}, title = {The function of Noto in the tail bud development}, keyword = {Noto, notochord, tail bud, embryo, mouse} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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