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Pregled bibliografske jedinice broj: 407982

Is the clinical picture of Schnitzler syndrome always Schnitzler syndrome?


Markotić, Alemka; Škerk, Višnja; Cvetko Krajinović, Lidija; Beus, Antun
Is the clinical picture of Schnitzler syndrome always Schnitzler syndrome? // Clinical and experimental rheumatology, 27 (2009), 3; 507-509 (podatak o recenziji nije dostupan, prikaz, znanstveni)


Naslov
Is the clinical picture of Schnitzler syndrome always Schnitzler syndrome?

Autori
Markotić, Alemka ; Škerk, Višnja ; Cvetko Krajinović, Lidija ; Beus, Antun

Izvornik
Clinical and experimental rheumatology (0392-856X) 27 (2009), 3; 507-509

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Ključne riječi
Schnitzler syndrome; interleukine (IL)-1; granulocytecolony stimulating factor (G-CSF); IL-32 alpha; IL-17E (IL-25); NK-cells; CD40L (CD154)

Sažetak
Here we present two cases, a female and a male patient with Schnitzler-like syndrome. Both patients had two major (monoclonal gammopathy and chronic urticaria) and almost all minor symptoms (e.g. arthralgia, bone pain, fever, etc.) of Schnitzler syndrome. It is considered that interleukine (IL)-1 has important influence on immunopathogenesis of Schnitzler syndrome. However, when looked at the immune response in our two patients, we found significant differences between them. In the sera of th efemale patient, IL-1beta was increased. However, the highest increase was found for granulocyte-colony stimulating factor (G-CSF), IL-32 alpha and IL-17E (IL-25). Th emale patient had a significant increase in th epercentage of NK-cells, a decrease in CD4+ helper cells and no increase in cytokine levels. In both patients an increase in CD40L (CD154) was found. Our statement is that, besides clinical symptoms and signs, additional immune parameters should be tested before diagnosis of Schnitzler syndrome is established.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-0000000-3489 - ODREĐIVANJE NAJRACIONALNIJE TERAPIJE EHINOKOKOZE (Dagny Stojčević, )
143-1080002-0050 - Dijagnostika i liječenje bolesnika sa sindromom prostatitisa (Višnja Škerk, )
143-1430115-0103 - Imunoreakcije na hantaviruse i leptospire (Alemka Markotić, )

Ustanove
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE