Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

INFLUENCE OF TNFd MICROSATELLITE POLYMORPHISM ON THE OUTCOME OF HEMATOPOIETIC STEM CELL TRANSPLANTATION (CROSBI ID 550737)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Štingl, Katarian ; Grubić, Zorana ; Čečuk-Jeličić, Esma ; Žunec, Renata ; Labar, Boris ; Serventi-Seiwerth, Ranka ; Brkljačić-Kerhin Vesna INFLUENCE OF TNFd MICROSATELLITE POLYMORPHISM ON THE OUTCOME OF HEMATOPOIETIC STEM CELL TRANSPLANTATION. 2008

Podaci o odgovornosti

Štingl, Katarian ; Grubić, Zorana ; Čečuk-Jeličić, Esma ; Žunec, Renata ; Labar, Boris ; Serventi-Seiwerth, Ranka ; Brkljačić-Kerhin Vesna

engleski

INFLUENCE OF TNFd MICROSATELLITE POLYMORPHISM ON THE OUTCOME OF HEMATOPOIETIC STEM CELL TRANSPLANTATION

Proinflammatory cytokines such as TNFα are released as a consequence of conditioning regimens performed prior to the hematopoietic stem cell transplantation (HSCT) and serum levels of TNFα have been shown to correlate with occurrence of posttransplantion complications such as acute GvHD. Previous studies have found an association between TNFα production and TNFd microsatellite polymorphism. The aim of the present study was to investigate the possible correlation between this polymorphism and the survival of patients. Eighty patients who underwent HSCT were included in the analysis. All of them received a transplant from a sibling identical for HLA-A, -B, and -DRB1 loci. The analysis of the TNFd microsatellite was performed using PCR amplification with specific primers followed by electrophoresis on a polyacrylamide gel in ALFexpress sequencer with the B cell lines from 10th Workshop as controls. The distribution of alleles at TNFd locus among the patients did not differ from the results obtained for healthy individuals tested in previous studies. The predominance of TNFd4 allele (53.8% and 56.6% respectively) was observed in both groups and the frequencies of all other alleles were in agreement. The patients were divided according to the survival at day 100 post HSCT. No statistically significant difference was observed between patients who survived longer than 100 days post HSCT (N=68) and those who have not (N=12) with respect to the distribution of allele and genotype frequencies at TNFd locus as well as to the percentage of homozygous individuals. No correlation with worse survival rates was observed for the presence of alleles with higher number of repeats as previously suggested. The only marginally significant difference was found for TNFd3 allele, which was increased among patients with worse survival. This finding is in agreement with previous reports

TNFd microsatellite; HSCT

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2008.

objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

22nd European Immunogenetics and Histocompatibility Conference

poster

01.04.2008-05.04.2008

Toulouse, Francuska

Povezanost rada

Kliničke medicinske znanosti