Napredna pretraga

Pregled bibliografske jedinice broj: 407506

Muscarinic and ganglionic blocking properties of atropine compounds in vivo and in vitro : time dependence and heart rate effects


Vicenzi, M.N.; Woehick, H.J.; Boban, Mladen; McCallum, B.; Atlee, J.L.; Bošnjak Željko J.
Muscarinic and ganglionic blocking properties of atropine compounds in vivo and in vitro : time dependence and heart rate effects // Canadian journal of physiology and pharmacology, 73 (1995), 4; 483-490 (međunarodna recenzija, članak, znanstveni)


Naslov
Muscarinic and ganglionic blocking properties of atropine compounds in vivo and in vitro : time dependence and heart rate effects

Autori
Vicenzi, M.N. ; Woehick, H.J. ; Boban, Mladen ; McCallum, B. ; Atlee, J.L. ; Bošnjak Željko J.

Izvornik
Canadian journal of physiology and pharmacology (0008-4212) 73 (1995), 4; 483-490

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Atropine sulfate; methylatropine nitrate; dominant and subsidiary atrial pacemakers; atrial dysrhythmias; excess tachycardia; postvagal tachycardia

Sažetak
High doses (3 mg/kg) of methylatropine nitrate have been used in vivo to produce long-lasting muscarinic blockade during physiologic experiments. At these levels, the possibility exists that ganglionic blockade may also be responsible for some heart rate effects. Therefore, the effects of methylatropine nitrate (0.0012-2.4 mg.kg(-1)) and atropine sulfate (0.0036 - 0.060 mg.kg(1)) were evaluated in vivo using conscious dogs and in vitro using canine right atria and isolated stellate ganglia. The lowest doses of either agent given in vivo caused bradycardia, while intermediate doses induced excess tachycardia. High doses of methylatropine nitrate transiently decreased the heart rate, followed by slow recovery. In vitro using the canine right atria, neither drug caused pacemaker shifts nor directly altered the atrial rate, but postvagal tachycardia occurred with acetylcholine challenge and was prevented by metoprolol or 6-hydroxydopamine. In vitro studies using the canine stellate ganglia indicate that both agents depressed postganglionic compound action potentials at high doses. In conclusion, with high-dose methylatropine nitrate, ganglionic blockade yields the mechanism for a reduction of excess tachycardia as well as a likely explanation for opposing chronotropic effects in conscious and anesthetized dogs. In experimental studies where high doses of atropine compounds are used for long-term muscarinic blockade, it is possible that ganglionic blocking effects may also be produced.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Autor s matičnim brojem:
Mladen Boban, (207836)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE