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Pregled bibliografske jedinice broj: 407166

Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation


Bach-Rojecky, Lidija; Dominis, Marija; Lacković, Zdravko
Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation // Fundamental & clinical pharmacology, 22 (2008), 5; 503-509 doi:10.1111/j.1472-8206.2008.00615.x (međunarodna recenzija, članak, znanstveni)


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Naslov
Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation

Autori
Bach-Rojecky, Lidija ; Dominis, Marija ; Lacković, Zdravko

Izvornik
Fundamental & clinical pharmacology (0767-3981) 22 (2008), 5; 503-509

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
botulinum toxin • capsaicin • carrageenan • inflammation • pain

Sažetak
Botulinum toxin type A (BTX-A) has a long-lasting antinociceptive activity and less clear effect on inflammation. It was proposed that these two effects share the same mechanism – the inhibition of neurotransmitter exocytosis from peripheral nerve endings. However, till now possible anti-inflammatory action of BTX-A did not evoke much attention. In the present paper, we investigate possible anti-inflammatory action of the toxin in carrageenan and capsaicin models of inflammation in rats. BTX-A (5 and 10 U/kg) was injected into the plantar surface of the rat right hind-paw pad 5 days before the injection of the carrageenan (1%) or capsaicin (0.1%) at the same site. Carrageenan-induced paw oedema and capsaicin-induced protein extravasation were measured. Control, inflamed and BTX-A pretreated inflamed paws were photographed and histopathological analysis (haematoxylin & eosin) was performed. Pretreatment with BTX-A had no effect on the size of carrageenan-induced paw oedema, measured as paw volume and weight or capsaicin-induced plasma extravasations, measured by Evans blue as a marker of protein leakage. Neither macroscopic nor microscopic analysis showed a significant difference between BTX-A pretreated and control inflamed tissue. Results show dissociation between the effect of BTX-A on pain and inflammation thus questioning the validity of the suggested assumption about the common peripheral mechanism of action.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Bach-Rojecky, Lidija; Dominis, Marija; Lacković, Zdravko
Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation // Fundamental & clinical pharmacology, 22 (2008), 5; 503-509 doi:10.1111/j.1472-8206.2008.00615.x (međunarodna recenzija, članak, znanstveni)
Bach-Rojecky, L., Dominis, M. & Lacković, Z. (2008) Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation. Fundamental & clinical pharmacology, 22 (5), 503-509 doi:10.1111/j.1472-8206.2008.00615.x.
@article{article, year = {2008}, pages = {503-509}, DOI = {10.1111/j.1472-8206.2008.00615.x}, keywords = {botulinum toxin and \#8226, capsaicin and \#8226, carrageenan and \#8226, inflammation and \#8226, pain}, journal = {Fundamental and clinical pharmacology}, doi = {10.1111/j.1472-8206.2008.00615.x}, volume = {22}, number = {5}, issn = {0767-3981}, title = {Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation}, keyword = {botulinum toxin and \#8226, capsaicin and \#8226, carrageenan and \#8226, inflammation and \#8226, pain} }
@article{article, year = {2008}, pages = {503-509}, DOI = {10.1111/j.1472-8206.2008.00615.x}, keywords = {botulinum toxin and \#8226, capsaicin and \#8226, carrageenan and \#8226, inflammation and \#8226, pain}, journal = {Fundamental and clinical pharmacology}, doi = {10.1111/j.1472-8206.2008.00615.x}, volume = {22}, number = {5}, issn = {0767-3981}, title = {Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation}, keyword = {botulinum toxin and \#8226, capsaicin and \#8226, carrageenan and \#8226, inflammation and \#8226, pain} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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