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Salivary levels of Il-2 and IL-6 cytokine in patients with zirconia crowns

OBJECTIVE: All-ceramic dental restorations have been extensively applied in prosthodontics in recent years due mainly to their improved esthetics and biocompatibilty ih compared with traditional metal-based prostheses.The use of toughened ceramics such as zirconia has widened the application of ceramics in dentistry. Good tissue tolerance is crucial for dental material usage since those materials come into direct contact with living tissue. AIM: Our study was undertaken to quantify the salivary levels of pro-inflammatory IL-2 and IL-6 in patients with zirconia crowns, compared with patients with amalgam restoration and with age-matched healthy control volunteers. SUBJECTS AND METHODS: Whole saliva from 20 patients with zirconia crowns, 20 from patients with amalgam restorations as well as from 20 healthy persons, was investigated for the presence of IL-2 and IL-6 by enzyme immunoassay. RESULTS: Salivary IL-2 and IL-6 levels were significantlly increased in patients with amalgam restorations in comparison with patients with zirconia crowns and healthy subjects. CONCLUSION: Saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity. The importance of the proposed analysis is reflected in the fact that the obtained results will enable choice of material which satisfies most of biological requirements. This will decrease the possibility for toxic and allergenic action of prosthodontic and restorative materials on the oral mucosa.

zirconia crown; IL-2; IL-6; salivary levels

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