engleski

Transfusion related acute lung injury (TRALI)

Transfusion-related acute lung injury (TRALI) is a complication following the transfusion of blood products and is potentially a life- threatening adverse event of transfusion. The first case of fatal pulmonary edema following transfusion was reported in 1951. In recent years, transfusion-related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of transfusion- related major morbidities and fatalities. A clinical definition of TRALI was established in 2004, based on acute respiratory distress which has temporal association with transfusion of blood components. In 2008 there was proposed distinction of classic and delayed syndrome. However pathophysiology of TRALI still remains controversial. A number of different models were proposed to explain the pathogenesis. At present there are two most accepted models which are not mutually exclusive. The first is antibody mediated model and the second is two event model. In this review article the definition of TRALI, patient predisposition, treatment, prevention and reporting guidelines are examined. The current knowledge on the topic TRALI is summarized.

acute respiratory distress ; pulmonary edema ; transfusion ; acute lung injury

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