Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 405425

Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice


Čulo, Filip; Renić, Marija; Sabolović, Domagoj; Radoš, Marko; Bilić, Ante; Jagić, Vjekoslav
Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice // European journal of gastroenterology & hepatology, 7 (1995), 8; 757-762 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 405425 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice

Autori
Čulo, Filip ; Renić, Marija ; Sabolović, Domagoj ; Radoš, Marko ; Bilić, Ante ; Jagić, Vjekoslav

Izvornik
European journal of gastroenterology & hepatology (0954-691X) 7 (1995), 8; 757-762

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ketoconazole ; acetaminophen ; hepatitis ; prostaglandins ; leukotriene C4

Sažetak
To investigate the effect of ketoconazole on acetaminophen (AAP)-induced hepatotoxicity in mice. Mice were given AAP intragastrically (300 mg/kg) and treated with ketoconazole (100mg/kg intraperitoneally) or saline either 30 min before or 2-3 h after AAP administration. Mortality was recorded for 48 h, during which all mice given saline either died or recovered fully. Serum alanine and aspartate transaminase levels were determined 24 h after administration of AAP. Prostaglandin E2, thromboxane A2 and leukotriene C4 production was determined 6h after AAP administration in the supernatants from the short-term culture of liver fragments by radioimmunoassay. Ketoconazole significantly decreased mortality and transaminase levels when given to mice either 30 min before or 2h after AAP. Liver fragments from mice with AAP hepatitis produced greater quantities of prostaglandin E2, thromboxane A2 and leukotriene C4 than fragments from normal liver. Pretreatment of mice with ketoconazole or its addition to liver fragments ex vivo further increased the production of prostaglandin E2 and reduced the production of thromboxane A2. The effect of ketoconazole on leukotriene C4 synthesis was different in vivo (synthesis stimulation) from in vitro (synthesis inhibition). The protective effect of ketoconazole in AAP hepatitis is most probably mediated by modulation of eicosanoid synthesis by liver cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Marko Radoš (autor)

Avatar Url Filip Čulo (autor)

Avatar Url Vjekoslav Jagić (autor)

Avatar Url Marija Renić (autor)

Citiraj ovu publikaciju

Čulo, Filip; Renić, Marija; Sabolović, Domagoj; Radoš, Marko; Bilić, Ante; Jagić, Vjekoslav
Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice // European journal of gastroenterology & hepatology, 7 (1995), 8; 757-762 (međunarodna recenzija, članak, znanstveni)
Čulo, F., Renić, M., Sabolović, D., Radoš, M., Bilić, A. & Jagić, V. (1995) Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. European journal of gastroenterology & hepatology, 7 (8), 757-762.
@article{article, year = {1995}, pages = {757-762}, keywords = {ketoconazole, acetaminophen, hepatitis, prostaglandins, leukotriene C4}, journal = {European journal of gastroenterology and hepatology}, volume = {7}, number = {8}, issn = {0954-691X}, title = {Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice}, keyword = {ketoconazole, acetaminophen, hepatitis, prostaglandins, leukotriene C4} }
@article{article, year = {1995}, pages = {757-762}, keywords = {ketoconazole, acetaminophen, hepatitis, prostaglandins, leukotriene C4}, journal = {European journal of gastroenterology and hepatology}, volume = {7}, number = {8}, issn = {0954-691X}, title = {Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice}, keyword = {ketoconazole, acetaminophen, hepatitis, prostaglandins, leukotriene C4} }

Časopis indeksira:


  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)





Contrast
Increase Font
Decrease Font
Dyslexic Font