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Pregled bibliografske jedinice broj: 405346

Protection of acute hepatotoxicity in mice by interleukin-1α - the role of interleukin-6 and prostaglandin E2


Renić, Marija; Čulo, Filip; Sabolović D
Protection of acute hepatotoxicity in mice by interleukin-1α - the role of interleukin-6 and prostaglandin E2 // Periodicum biologorum, 97 (1995), 1; 55-60 (podatak o recenziji nije dostupan, članak, znanstveni)


CROSBI ID: 405346 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Protection of acute hepatotoxicity in mice by interleukin-1α - the role of interleukin-6 and prostaglandin E2

Autori
Renić, Marija ; Čulo, Filip ; Sabolović D

Izvornik
Periodicum biologorum (0353-9164) 97 (1995), 1; 55-60

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acetaminophen; hepatotoxicity; interleukin-lα; interleukin-6; prostaglandin E2; D-galactosamine; lipopolysaccharide

Sažetak
Background and Purpose. We have shown previously that IL-la is highly protective in mice with acute hepatototoxicity induced by AAP In these experiments we investigated whether PCE2 and IL-6 are involved in IL-la-induced hepatoprotection. In addition, we investigated the effect of spontaneously produced IL-6 on AAP-induced hepatotoxicity, and the ef&not ; fect of IL-la on heptotoxicity induced by LPS in D-galactosamine sensi&not ; tized mice. Materials and Methods. The mice received toxic dose of AAP by gas&not ; tric route. Recombinant human IL-lα or recombinant mouse IL-6 were given to mice i.p. 2 hours before AAP polycolnal anti-PGE2 and mono&not ; clonal anti-IL-6 antibodies were given 3 hours before IL-lα , or, when given alone, 5 hours before AAP The mortality of mice was followed, and serum aminotransferase levels (AST and ALT) were determined 24 hours after the AAP administration. Results. IL-lα significantly reduced and the serum ALT and AST levels in the AAP-treated mice. It also decreased the mortality of mice which re&not ; ceived LPS after D-galactosamine. Pretreatment of mice with anti-PGE2 or anti-IL-6 antibodies before IL-lα administration decreased its protective effect in those with AAP-induced hepatotoxicity. Administration of anti-IL-6 antibodies alone before AAP increased the mortality of mice and the se&not ; rum aminotransferase levels, while, in contrast, administration of recombinant mouse IL-6 before AAP had the opposite, i.e. beneficial effect. Conclusion. Both PGE2 and IL-6 mediate, perhaps in mutually interde&not ; pendent way, the hepatoprotective effect of IL-lα .

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Marija Renić (autor)

Avatar Url Filip Čulo (autor)


Citiraj ovu publikaciju

Renić, Marija; Čulo, Filip; Sabolović D
Protection of acute hepatotoxicity in mice by interleukin-1α - the role of interleukin-6 and prostaglandin E2 // Periodicum biologorum, 97 (1995), 1; 55-60 (podatak o recenziji nije dostupan, članak, znanstveni)
Renić, M., Čulo, F. & Sabolović D (1995) Protection of acute hepatotoxicity in mice by interleukin-1α - the role of interleukin-6 and prostaglandin E2. Periodicum biologorum, 97 (1), 55-60.
@article{article, year = {1995}, pages = {55-60}, keywords = {acetaminophen, hepatotoxicity, interleukin-l and \#945, , interleukin-6, prostaglandin E2, D-galactosamine, lipopolysaccharide}, journal = {Periodicum biologorum}, volume = {97}, number = {1}, issn = {0353-9164}, title = {Protection of acute hepatotoxicity in mice by interleukin-1 and \#945; - the role of interleukin-6 and prostaglandin E2}, keyword = {acetaminophen, hepatotoxicity, interleukin-l and \#945, , interleukin-6, prostaglandin E2, D-galactosamine, lipopolysaccharide} }
@article{article, year = {1995}, pages = {55-60}, keywords = {acetaminophen, hepatotoxicity, interleukin-l and \#945, , interleukin-6, prostaglandin E2, D-galactosamine, lipopolysaccharide}, journal = {Periodicum biologorum}, volume = {97}, number = {1}, issn = {0353-9164}, title = {Protection of acute hepatotoxicity in mice by interleukin-1 and \#945; - the role of interleukin-6 and prostaglandin E2}, keyword = {acetaminophen, hepatotoxicity, interleukin-l and \#945, , interleukin-6, prostaglandin E2, D-galactosamine, lipopolysaccharide} }

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