Systemic administration of bone morphogenetic proteins (CROSBI ID 38615)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Vukičević, Slobodan ; Šimić, Petra ; Grgurević, Lovorka ; Borovečki, Fran ; Sampath, Kuber
engleski
Systemic administration of bone morphogenetic proteins
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.
bone morphogenetic proteins, osteoporosis, renal failure
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Podaci o prilogu
317-338.
objavljeno
Podaci o knjizi
Bone Morphogenetics Proteins: From Local to Systemic Therapeutics
Vukičević, Slobodan ; Sampath, Kuber
Basel : Boston : Berlin: Birkhäuser
2008.
3764385510