engleski

The effect of interleukin-1α on acetaminophen-induced hepatotoxicity

The protective effect of interleukin lα (IL-lα ) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-lα had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP ; it significantly reduced mortality of mice and decreased serum transaminase level. The maximal effect was obtained with the dose of 1000 U (166 ng/kg)IL-lalpha. Pretreatment with IL-1 significantly increased the synthesis of prostaglandin E, (PGE, )in samples of liver tissue from AAP-treated mice, but had no effect on the synthesis of leukotriene C, (LTC4). Pretreatment with indomethacin (IMC) did not abrogate significantly the protective effect of IL-l. Thus, the hepatoprotective effect of IL-lα can not be entirely explained by the stimulation of prostaglandin (PG) synthesis.

interleukin lα /acetaminophen/hepatitis/leukotriene C

nije evidentirano