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Pregled bibliografske jedinice broj: 404908

Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients


Morović-Vergles, Jadranka; Čulo, Melanie-Ivana; Gamulin, Stjepan; Čulo, Filip
Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients // Rheumatology international, 29 (2008), 2; 167-171 doi:10.1007/s00296-008-0663-z (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 404908 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients

Autori
Morović-Vergles, Jadranka ; Čulo, Melanie-Ivana ; Gamulin, Stjepan ; Čulo, Filip

Izvornik
Rheumatology international (0172-8172) 29 (2008), 2; 167-171

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
osteoarthritis; synovial fluid; cyclic AMP; prostaglandin E2; interleukin-18

Sažetak
The relationship between synovial fluid (SF) cAMP level and IL-18 and PGE2 SF levels in rheumatoid arthritis (RA) and osteoarthritis (OA) patients, and between SF cAMP level and disease as well as inflammatory activity in RA were investigated in 17 RA and 19 OA patients. Erythrocyte sedimentation rate (ESR), serum (S) C-reactive protein (CRP) level and SF IL-18 level were higher in RA than in OA patients. SF PGE2 level was similar in both groups. SF cAMP level was higher in OA than in RA patients. In RA patients, SF cAMP level showed negative correlation with Disease Activity Score including a 28-joint count and S CRP, ESR and SF IL-18 level. The results suggest that cAMP promotes anti-inflammatory response in RA and OA patients, which is higher in the latter. Promotion of anti-inflammatory response by cAMP elevating agents might be useful in the treatment of RA.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre
198-1081874-0183 - Patogeneza sustavnih poremećaja u reumatoidnom artritisu (Morović-Vergles, Jadranka, MZOS ) ( POIROT)
219-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre (Čulo, Filip, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Morović-Vergles, Jadranka; Čulo, Melanie-Ivana; Gamulin, Stjepan; Čulo, Filip
Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients // Rheumatology international, 29 (2008), 2; 167-171 doi:10.1007/s00296-008-0663-z (međunarodna recenzija, članak, znanstveni)
Morović-Vergles, J., Čulo, M., Gamulin, S. & Čulo, F. (2008) Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients. Rheumatology international, 29 (2), 167-171 doi:10.1007/s00296-008-0663-z.
@article{article, year = {2008}, pages = {167-171}, DOI = {10.1007/s00296-008-0663-z}, keywords = {osteoarthritis, synovial fluid, cyclic AMP, prostaglandin E2, interleukin-18}, journal = {Rheumatology international}, doi = {10.1007/s00296-008-0663-z}, volume = {29}, number = {2}, issn = {0172-8172}, title = {Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients}, keyword = {osteoarthritis, synovial fluid, cyclic AMP, prostaglandin E2, interleukin-18} }
@article{article, year = {2008}, pages = {167-171}, DOI = {10.1007/s00296-008-0663-z}, keywords = {osteoarthritis, synovial fluid, cyclic AMP, prostaglandin E2, interleukin-18}, journal = {Rheumatology international}, doi = {10.1007/s00296-008-0663-z}, volume = {29}, number = {2}, issn = {0172-8172}, title = {Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients}, keyword = {osteoarthritis, synovial fluid, cyclic AMP, prostaglandin E2, interleukin-18} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Immunology Abstracts


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