Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients (CROSBI ID 151885)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Morović-Vergles, Jadranka ; Čulo, Melanie-Ivana ; Gamulin, Stjepan ; Čulo, Filip
engleski
Cyclic adenosine 5'-monophosphate (cAMP) in synovial fluid of rheumatoid arthritis and osteoarthritis patients
The relationship between synovial fluid (SF) cAMP level and IL-18 and PGE2 SF levels in rheumatoid arthritis (RA) and osteoarthritis (OA) patients, and between SF cAMP level and disease as well as inflammatory activity in RA were investigated in 17 RA and 19 OA patients. Erythrocyte sedimentation rate (ESR), serum (S) C-reactive protein (CRP) level and SF IL-18 level were higher in RA than in OA patients. SF PGE2 level was similar in both groups. SF cAMP level was higher in OA than in RA patients. In RA patients, SF cAMP level showed negative correlation with Disease Activity Score including a 28-joint count and S CRP, ESR and SF IL-18 level. The results suggest that cAMP promotes anti-inflammatory response in RA and OA patients, which is higher in the latter. Promotion of anti-inflammatory response by cAMP elevating agents might be useful in the treatment of RA.
osteoarthritis; synovial fluid; cyclic AMP; prostaglandin E2; interleukin-18
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija