engleski

The association of platelet GPIbα 145Thr/Met (HPA-2a/2b) with myocardial infarction and coronary artery disease

We aimed to investigate if the GPIbα 145Thr/Met (HPA-2a/2b) is associated with fatal pre- hospital myocardial infarction (MI) and coronary artery disease (CAD), aiming to find a genetic marker that could be used in the early (pre-clinical) disease diagnostics and possibly even disease prevention. A total of 402 cases of MI and CAD were included in the study (201 cases of CAD and 201 cases with both CAD and MI), supplemented with 202 controls (defined as the patients who underwent coronarography and had not been diagnosed with any of the two diagnoses). Genotyping was performed using PCR LightCycler  2 . The analysis was performed using Fisher's exact test, due to the small number of homozygous (Met/Met) cases. The results suggest that the prevalence of homozygous Met/Met was much higher in cases than controls, thus suggesting that it might be utilized as the disease prevention marker. The difference was significant (P=0.021). However, the application of the logistic regression model with age and gender as the additional covariates indicated the increasing trend of the risk among the GPIbα genotypes (Thr/Thr was used as the referent group, Thr/Met had an odds ratio of 1.18 [95% confidence intervals 0.76- 1.82], while Met/Met had an odds ratio of 3.01 [0.32-28.37] ; the difference was not significant ; P=0, 494).

platelet polymorphism ; myocardial infarction ; coronary artery disease

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