engleski

Surveillance of neuro-immunological liaison by NF-kB activation in different cell types

Although considered as an immune privileged site, a tight functional link betwen the Central Nervous System and Peripheral Immune System closely related to the activity of NF-kB transcription factor has been evidenced in numerous brain pathological conditions. One of the most instructive examples is prion neuroinvasion and development of transmissible spongiform encephalopaty (TSE) or prion disease. The new insight into the molecular requirements for follicular stromal cell and FDC development in NF-kB deficient mice highlights the role of NF-kB transcription factor in prion disease progression. Perivascular macrophages represent the major pool of cells which become quickly replenished following hypoxic stress or inflammation. How lack of NF-kB activity withihn this cellular compartment influences this response is not clear. RT-PCR analysis of the expression level of of mRNA for LTa, LTb, TNFRI and BLC of the splenic cells from p52/NF-kB mutant/wt BM chimera did not reveal major changes compared to wt/wt BM chimeras, indicating that their normal expression within splenic tissue does not assure for complete restoration of FDC network in p52/NF-kB mutant.In these mice the distance between FDC clusters within secondary germinal centers and splenic nerve terminals is impaired which may represent an important observation from the point of view of prion disaese development but also its therapy.

Follicular dendritic cells; MOMA-1+ perivascular macrophages; BM chimera

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