engleski

Genetic polymorphisms in RSA susceptibility – a systematic review of immunity-related genes

Problem The genetic background of recurrent spontaneous abortion (RSA) has been widely investigated and confirmed through its familial occurrence, linkage analysis and epidemiologic studies. A polygenic inheritance has been suggested and a number of association studies have been performed with the aim of identifying candidate genes, including genes coding coagulation factors, oxidative stress, vasoactive substances, endocrine and metabolic factors and genes involved in immunological processes. Method of study In order to avoid contradictions between reports, uncertainties regarding false positive or false negative associations, and to ensure certainty in statistical analyses due to sample sizes, a systematic review of the studies on candidate genes related to immunology involved in RSA was performed. The PUBMED and EMBASE databases were searched up for studies on candidate genes in RSA. All case-control studies were registered and those satisfying principles of evidence based medicine were included in further analysis. Results Up to December 2006, 172 citations were registered ; while 65 among them were studies of genetic polymorphisms in immunity– related genes. The most frequently investigated genes included HLA system (25), TNF (8), IL-10 (7) and IL-6 (6). Large variation among reported results in studies was found. Conclusions The magnitude of the association between polymorphism in the immunity-related genes and RSA varies, according to the type of RSA and the type of gene/ polymorphism investigated. Further studies are needed to assess polymorphisms in immunity-related genes as the RSA risk factors.

recurrent spontaneous abortion susceptibility; genetic polymorphisms; immunity-related genes

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