engleski

THE ROLE OF OBESITY PREVENTION FOR PROTECTION OF IMMUNE RESPONSE AND HEALTH IMPROVEMENT

Introduction: Obesity is complex multifactor disease that is developed as interaction of genotypes and external influence. Diminished physical activities, sessile type of life, social, cultural, psychic and metabolic factors, as well as non appropriate food intake with more other endogen and exogenous factors lead to development of obesity and lost of good innate and acquired immunity. Diminished or lack of physical activities in obese adults may lead to great socio-economic risk of developing grate number of serious complications: allergic diseases, augmented concentration of IgE and decreased immune response. Furthermore, obesity may include decreased number of B-cells, as well as the augmented number of T helper cells-type 2. Intensive exercises with reduced body mass affect positive on the immune response less producing of proinflammatory cytokines, thymus hematophoesis and good T-cell producing, as well as limphophoesis of B-cells. The aim of the study: to investigate the immunological status of obesity group of patients and compare them with the level of obesity, as well as with the appearance of other common disorders in obesity adult. Results: Appearance of illnesses such as: higher fats (p<0, 05), varicose veins (p<0, 05), hart disorders (p<0, 05), diabetes (p<0, 05), digestion disorders (p<0, 05) are significant for obesity level and they extremely change the quality of life. Obese adults have significant socio-economic risk of developing anxiety. Anxiety is growing along with aging (p<0, 05), decreasing economic status (p<0, 05), low education (p<0, 05) and place of living, if it&#8217; s a city (p<0, 05). Our obesity patients were decreased number of NK and NKT cells, as well as B and CD4+ cells Conclusion: Our preliminary data indicate the connection of obesity and lower immunological response, which correlate with obesity level and higher incidence in many other disorders. Acknowledgment: This work was supported by grant from the Croatian Ministry of Science (project no.0620096-0094)

immune response; obesity; physical activities; T cells

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