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Pregled bibliografske jedinice broj: 401533

Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma


Čretnik, Maja; Poje, Gorazd; Musani, Vesna; Krušlin, Božo; Ozretić, Petar; Tomas, Davor; Šitum, Mirna; Levanat, Sonja
Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma // International journal of oncology, 34 (2009), 4; 1045-1050 doi:10.3892/ijo_00000230 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 401533 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma

Autori
Čretnik, Maja ; Poje, Gorazd ; Musani, Vesna ; Krušlin, Božo ; Ozretić, Petar ; Tomas, Davor ; Šitum, Mirna ; Levanat, Sonja

Izvornik
International journal of oncology (1019-6439) 34 (2009), 4; 1045-1050

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
p16 ; PTCH ; melanoma ; basal cell carcinoma ; signaling pathways

Sažetak
The involvement of two tumor suppressors p16 and Ptch in pathogenesis of cutaneous melanomas and basal cell carcinomas (BCCs) was studied through expression of Ptch and p16 and genetic alterations in 9p21 region (p16) and in 9q22.3 region (PTCH) of chromosome 9. Immunohistochemical analyses of paraffin-embedded tissues with Ptch and p16 antibodies, typing for 9q22-q31 and 9p21 region with polymorphic markers and p16 and Ptch mutation detection was done. Higher expression of p16 and Ptch in melanoma and BCC of the skin was frequently detected in studied cases. However, allelic loss of PTCH region occurs more frequently in BCCs than loss of heterozygosity of p16 region. Both types of tumors, BCCs and melanomas, suggest involvement of Hh-Gli signaling pathway, but using different mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2461 - Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije (Levanat, Sonja, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Gorazd Poje (autor)

Avatar Url Vesna Musani (autor)

Avatar Url Petar Ozretić (autor)

Avatar Url Mirna Šitum (autor)

Avatar Url Božo Krušlin (autor)

Avatar Url Sonja Levanat (autor)

Avatar Url Davor Tomas (autor)

Avatar Url Maja Sabol (autor)

Citiraj ovu publikaciju

Čretnik, Maja; Poje, Gorazd; Musani, Vesna; Krušlin, Božo; Ozretić, Petar; Tomas, Davor; Šitum, Mirna; Levanat, Sonja
Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma // International journal of oncology, 34 (2009), 4; 1045-1050 doi:10.3892/ijo_00000230 (međunarodna recenzija, članak, znanstveni)
Čretnik, M., Poje, G., Musani, V., Krušlin, B., Ozretić, P., Tomas, D., Šitum, M. & Levanat, S. (2009) Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma. International journal of oncology, 34 (4), 1045-1050 doi:10.3892/ijo_00000230.
@article{article, year = {2009}, pages = {1045-1050}, DOI = {10.3892/ijo\_00000230}, keywords = {p16, PTCH, melanoma, basal cell carcinoma, signaling pathways}, journal = {International journal of oncology}, doi = {10.3892/ijo\_00000230}, volume = {34}, number = {4}, issn = {1019-6439}, title = {Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma}, keyword = {p16, PTCH, melanoma, basal cell carcinoma, signaling pathways} }
@article{article, year = {2009}, pages = {1045-1050}, DOI = {10.3892/ijo\_00000230}, keywords = {p16, PTCH, melanoma, basal cell carcinoma, signaling pathways}, journal = {International journal of oncology}, doi = {10.3892/ijo\_00000230}, volume = {34}, number = {4}, issn = {1019-6439}, title = {Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma}, keyword = {p16, PTCH, melanoma, basal cell carcinoma, signaling pathways} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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