engleski

Depression dependent homology of the human hair and whole blood multielement profile.

Multielement profile analysis of the hair (H) and whole blood (WB) biological matrice allows for the study of the element metabolism in their mutual context. The aim of this study was to explore the role of depression on the multielement profile pattern of depressed (33 women and 15 men) and control subjects (25 women and 23 men) of adult age. Depression was diagnosed according to the DSM-IV criteria. The study was conducted by follovving the ethical principles of the Declaration of Helsinki on Human Subject Research. Forty one element were analyzed in the occipital scalp H and WB by the ICP MS (Elan 9000, Perkin Elmer, USA), (Momčilović et al. TEM (Moscovv), 2006 ; 7(4): 35-42). Median difference of an element of 10% or more betvveen control and depressed subjects was considered to be significant. The results allovvs for element grouping into four homologous patterns: Depressed>Control (H, WB): Ag, As, B, Ba, Cd, Ga, Ge, La, Li, Mn, Rb, Sb, V, W Control>Depressed (H, WB): Bi, Se Depressed (H>WB), Control (WB>H): K, Na Control (H>WB), Depressed (WB>H): Au, Cu, Hg, Mg, Sr, Zr Other studied elements did not show such a simple depression dependent homologous pattern betvveen the hair and the vvhole blood (Al, Be, Ca, Co, Cr, Fe, I, Mo, Ni, P, Pb, Pt, Si, Sn, Ti, TI, Zn), albeit more complex associations can't be excluded at this time. Evidently, there is a long list of predominantly non- essential elements that are higher in both H and WB of depressed than in the healthy control subjects. It's not surprising that the essential Se is decreased in depression, but the same hold for Bi considered to be non-essential. The fact about the high K and Na in the hair of depressed as opposed to the blood of control subjects is intriguing since it indicates some basic discrepancy in the control of the vvater and electrolytes balance to be at the ćore of the depression. Acknovvledgements. This work vvas supported by the RCI, Isle of Man, UK ; the McDonald's, Zg, CRO ; and the MZOS, Zg, CRO, Grant 292-0222412-2405.

Depression; multielement profile; hair; whole blood

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