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Depression dependent homology of the human hair and whole blood multielement profile.


Momčilović, Berislav; Morović, Jadran; Prejac, Juraj; Morović, Sandra; Mimica, Ninoslav; Bezić, Irena; Radionov, Tanja; Svirč, Ankica; Skalny, Anatoly V.; Skalnaya, Margarita G.
Depression dependent homology of the human hair and whole blood multielement profile. // Book of abstracts - 13th International Meeting on Trace Elemens in Man and Animals (TEMA 13) - Trace elements from the Andes to the world
Pucon, 2008. str. 140-140 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Depression dependent homology of the human hair and whole blood multielement profile.

Autori
Momčilović, Berislav ; Morović, Jadran ; Prejac, Juraj ; Morović, Sandra ; Mimica, Ninoslav ; Bezić, Irena ; Radionov, Tanja ; Svirč, Ankica ; Skalny, Anatoly V. ; Skalnaya, Margarita G.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts - 13th International Meeting on Trace Elemens in Man and Animals (TEMA 13) - Trace elements from the Andes to the world / - Pucon, 2008, 140-140

Skup
13th International Meeting on Trace Elemens in Man and Animals. Trace elements from the Andes to the world

Mjesto i datum
Pucon, Čile, 09-13.11.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Depression; multielement profile; hair; whole blood

Sažetak
Multielement profile analysis of the hair (H) and whole blood (WB) biological matrice allows for the study of the element metabolism in their mutual context. The aim of this study was to explore the role of depression on the multielement profile pattern of depressed (33 women and 15 men) and control subjects (25 women and 23 men) of adult age. Depression was diagnosed according to the DSM-IV criteria. The study was conducted by follovving the ethical principles of the Declaration of Helsinki on Human Subject Research. Forty one element were analyzed in the occipital scalp H and WB by the ICP MS (Elan 9000, Perkin Elmer, USA), (Momčilović et al. TEM (Moscovv), 2006 ; 7(4): 35-42). Median difference of an element of 10% or more betvveen control and depressed subjects was considered to be significant. The results allovvs for element grouping into four homologous patterns: Depressed>Control (H, WB): Ag, As, B, Ba, Cd, Ga, Ge, La, Li, Mn, Rb, Sb, V, W Control>Depressed (H, WB): Bi, Se Depressed (H>WB), Control (WB>H): K, Na Control (H>WB), Depressed (WB>H): Au, Cu, Hg, Mg, Sr, Zr Other studied elements did not show such a simple depression dependent homologous pattern betvveen the hair and the vvhole blood (Al, Be, Ca, Co, Cr, Fe, I, Mo, Ni, P, Pb, Pt, Si, Sn, Ti, TI, Zn), albeit more complex associations can't be excluded at this time. Evidently, there is a long list of predominantly non- essential elements that are higher in both H and WB of depressed than in the healthy control subjects. It's not surprising that the essential Se is decreased in depression, but the same hold for Bi considered to be non-essential. The fact about the high K and Na in the hair of depressed as opposed to the blood of control subjects is intriguing since it indicates some basic discrepancy in the control of the vvater and electrolytes balance to be at the ćore of the depression. Acknovvledgements. This work vvas supported by the RCI, Isle of Man, UK ; the McDonald's, Zg, CRO ; and the MZOS, Zg, CRO, Grant 292-0222412-2405.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
022-0222412-2405 - Metali - biokompatibilnost i stres u alopeciji, depresiji i dijabetesu (Berislav Momčilović, )
292-0222412-2405 - Metali - biokompatibilnost i stres u alopeciji, depresiji i dijabetesu (Berislav Momčilović, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb,
Institut za istraživanje i razvoj održivih eko sustava