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Pregled bibliografske jedinice broj: 401232

Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study


Francetić, Igor; Kalenić, Smilja; Huić, Mirjana; Merčep, Iveta; Makar-Aušperger, Ksenija; Likić, Robert; Erdeljić, Viktorija; Tripković, Vesna; Šimić, Petra
Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study // Croatian medical journal, 49 (2008), 2; 207-214 doi:10.3325/cmj.2008.2.207 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 401232 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study

Autori
Francetić, Igor ; Kalenić, Smilja ; Huić, Mirjana ; Merčep, Iveta ; Makar-Aušperger, Ksenija ; Likić, Robert ; Erdeljić, Viktorija ; Tripković, Vesna ; Šimić, Petra

Izvornik
Croatian medical journal (0353-9504) 49 (2008), 2; 207-214

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aminoglycoside; cycling; tertiary intensive care units; longitudinal interventional study

Sažetak
To determine the effect of aminoglycoside cycling in six tertiary intensive care units (ICU) on the rates of sepsis, aminoglycoside resistance patterns, antibiotic consumption, and costs. This was a prospective longitudinal interventional study that measured the effect of change from first-line gentamicin usage (February 2002-February 2003) to amikacin usage (February 2003-February 2004) on the aminoglycoside resistance patterns, number of patients with gram-negative bacteremia, consumption of antibiotics, and the cost of antimicrobial drugs in 6 tertiary care ICUs in Zagreb, Croatia. The change from first-line gentamicin to amikacin usage led to a decrease in the overall gentamicin resistance of gram-negative bacteria (GNB) from 42% to 26% (P<0.001 ; z-test of proportions) and netilmicin resistance from 33% to 20% (P<0.001), but amikacin resistance did not change significantly (P=0.462), except for Acinetobacter baumanni (P=0.014). Sepsis rate in ICUs was reduced from 3.6% to 2.2% (P<0.001 ; chi(2) test), with a decline in the number of nosocomial bloodstream infections from 55/100 patient-days to 26/100 patient-days (P=0.001, chi(2) test). Furthermore, amikacin use led to a 16% decrease in the overall antibiotic consumption and 0.1 euro/patient/d cost reduction. Exclusive use of amikacin significantly reduced the resistance of GNB isolates to gentamicin and netilmicin, the number of GNB nosocomial bacteremias, and the cost of total antibiotic usage in ICUs

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080114-0016 - Modifikacija antimikrobne terapije i rezistencija patogenih mikroorganizama (Francetić, Igor, MZOS ) ( POIROT)
108-1080114-0017 - Genotipovi i činitelji virulencije uzročnika bolničkih infekcija (Budimir, Ana, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Francetić, Igor; Kalenić, Smilja; Huić, Mirjana; Merčep, Iveta; Makar-Aušperger, Ksenija; Likić, Robert; Erdeljić, Viktorija; Tripković, Vesna; Šimić, Petra
Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study // Croatian medical journal, 49 (2008), 2; 207-214 doi:10.3325/cmj.2008.2.207 (međunarodna recenzija, članak, znanstveni)
Francetić, I., Kalenić, S., Huić, M., Merčep, I., Makar-Aušperger, K., Likić, R., Erdeljić, V., Tripković, V. & Šimić, P. (2008) Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study. Croatian medical journal, 49 (2), 207-214 doi:10.3325/cmj.2008.2.207.
@article{article, year = {2008}, pages = {207-214}, DOI = {10.3325/cmj.2008.2.207}, keywords = {aminoglycoside, cycling, tertiary intensive care units, longitudinal interventional study}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2008.2.207}, volume = {49}, number = {2}, issn = {0353-9504}, title = {Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study}, keyword = {aminoglycoside, cycling, tertiary intensive care units, longitudinal interventional study} }
@article{article, year = {2008}, pages = {207-214}, DOI = {10.3325/cmj.2008.2.207}, keywords = {aminoglycoside, cycling, tertiary intensive care units, longitudinal interventional study}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2008.2.207}, volume = {49}, number = {2}, issn = {0353-9504}, title = {Impact of aminoglycoside cycling in six tertiary intensive care units: prospective longitudinal interventional study}, keyword = {aminoglycoside, cycling, tertiary intensive care units, longitudinal interventional study} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • MEDLINE


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