Synthesis and Biotransformations of Quaternary Quinuclidine Compounds (CROSBI ID 549220)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Primožič, Ines ; Baumann, Krešimir ; Tomić, Srđanka
engleski
Synthesis and Biotransformations of Quaternary Quinuclidine Compounds
Optically active quinuclidines are parts of several alkaloids and important intermediates in the preparation of pharmacologically active compounds. Therefore, interactions with various biomolecules as well as methods for the efficient production of chiral quinuclidines are examined. It has been shown that stereoselectivity of hydrolyses catalysed by butyrylcholinesterase (BChE ; EC 3.1.1.8) was in favour of the (R)-enantiomers in the case of quinuclidinium esters and amides.1-5 In order to further investigate structure-activity relationship of enyzme and quinuclidine esters and amides, several different racemic and enantiomerically pure quinuclidium derivatives were synthesized. All compounds were then tested as substrates and/or inhibitors of a horse serum butyrylcholinesterase. Dependence of butyrylcholinesterase activity and enantioselectivity on the substrate's acyl structure, preference of butyrylcholinesterase towards (R)-enantiomers and the differences in the rates of hydrolysis depending on the quaternary ammonium and acyl group will be discussed.
butyrylcholinesterase ; quinuclidinium derivatives ; kinetic study ; resolution of enantiomers
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Podaci o prilogu
29-29.
2009.
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objavljeno
978-953-6894-38-3
Podaci o matičnoj publikaciji
XXI. hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka
Novak, Predrag
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
Podaci o skupu
XXI. Hrvatski skup kemičara i kemijskih inženjera
pozvano predavanje
19.07.2009-22.07.2009
Trogir, Hrvatska