Seryl-tRNA Synthetases : Enzymes with Multiple Personalities (CROSBI ID 151040)
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Podaci o odgovornosti
Bilokapić, Silvija ; Ban, Nenad ; Weygand-Đurašević, Ivana
engleski
Seryl-tRNA Synthetases : Enzymes with Multiple Personalities
Seryl-tRNA synthetases (SerRS) are essential enzymes responsible for aminoacylation of cognate transfer-RNAs (tRNAsSer) with serine, which is then incorporated into the proteins being synthesized on the ribosome. Although tRNA synthetases are usually a very conserved class of enzymes, phylogenic analyses revealed the existence of two distinct types of serine-charging enzymes ; a standard or bacterial-type SerRS is found in the majority of organisms (prokaryotes, eukaryotes and archaea), while a highly diverged methanogenic-type SerRS is confined to the methanogenic archaea. We give a short overview on our recent biochemical and structural contributions to the understanding of different molecular mecha-nisms of tRNA serylation.
seryl-tRNA synthetase; transfer RNA; synthetase crystal structure; synthetase:tRNA model
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