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Pregled bibliografske jedinice broj: 399370

Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases


Pham, Bach-Nga; Rudić, Milan; Bouccara, Didier; Sterkers, Olivier; Belmatoug, Nadia; Bebear, Jean-Pierre; Couloigner, Vincent; Fraysse, Bernard; Gentine, Andre; Ionescu, Eugene et al.
Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases // Autoimmunity, 40 (2007), 3; 202-207 doi:10.1080/08916930701248555 (međunarodna recenzija, članak, znanstveni)


Naslov
Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases

Autori
Pham, Bach-Nga ; Rudić, Milan ; Bouccara, Didier ; Sterkers, Olivier ; Belmatoug, Nadia ; Bebear, Jean-Pierre ; Couloigner, Vincent ; Fraysse, Bernard ; Gentine, Andre ; Ionescu, Eugene ; Robier, Alain ; Sauvage, Jean-Pierre ; Truy, Eric ; Van Den Abbeele, Thierry ; Ferrary, Evelyne

Izvornik
Autoimmunity (0891-6934) 40 (2007), 3; 202-207

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hearing loss; vertigo; Menire's disease; MPZ; myelin P0 protein

Sažetak
The inner ear can be the target of autoimmune disorders. Recognition of autoimmune inner ear disease is important, as it is one of the very few forms of sensorineural hearing loss (HL) that can be successfully treated by medical therapy. The aim of this study was to evaluate whether the detection of antibodies to myelin protein P0 (MPZ) could be a diagnostic test for inner ear disease of autoimmune cause. This multicentric prospective study included 129 patients: patients with progressive sensorineural HL or with Meniè ; re's disease, together with their control group corresponding to patients with similar symptoms, but of presumably known origin. Detection of antibodies to myelin P0 protein was performed by using western blots. The prevalence of antibodies to myelin P0 protein in patients with rapidly progressive HL was not statistically different from that of the control group corresponding to genetic HL patients (30 versus 28%). In patients with Meniè ; re's disease, the prevalence was lower than that of the control group corresponding to patients with benign paroxysmal positional vertigo (5.4 versus 18.7%). No patient with auto-immune disease had antibodies to myelin P0 protein. The sole presence of antibodies to myelin P0 may not be used as a marker of inner ear disease of autoimmune origin.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2510 - Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima (Magdalena Grce, )
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )

Ustanove
Opća bolnica Zadar,
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Milan Rudić, (260756)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemoreception Abstracts


Citati