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Is nasal hyperreactive response to non-isotonic aerosol related to the level of inflammation (CROSBI ID 548921)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Zurak, Krešo ; Vagić, Davor ; Baudoin, Tomislav ; Solter, Darko ; Kalogjera, Livije Is nasal hyperreactive response to non-isotonic aerosol related to the level of inflammation // Abstract book of the 7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN) / Scadding, Glenis ; Kalogjera, Livije (ur.). Zagreb, 2008. str. 67-x

Podaci o odgovornosti

Zurak, Krešo ; Vagić, Davor ; Baudoin, Tomislav ; Solter, Darko ; Kalogjera, Livije

engleski

Is nasal hyperreactive response to non-isotonic aerosol related to the level of inflammation

A significant increase in nasal resistance is observed in patients with allergic and non-allergic rhinitis after nasal inhalation of distilled water mist. The purpose of the study was to compare hyperreactive response to nasal distilled water provocation in the patients with allergic and non-allergic hyperreactive rhinitis with the level of inflammatory cell activation markers prior to provocation. The study was performed on a group of 78 patients with nasal hyperreactivity according to patient history, 48 patients with allergic rhinitis and 30 patients with non-infectious non-allergic rhinitis (NINAR). The concentrations of eosinophil cationic protein (ECP), myeloperoxidase (MPO) and tryptase (TRY) were measured in the nasal lavage prior to provocation. Basal nasal airway resistance (NAR) was measured by active anterior rhinomanometry, and nasal lavage with 5 ccm of saline was taken. The provocation was made by inhalation of 10 ccm of distilled water during 10 minutes. The patients were divided in three subgroups according to NAR increase (0, 50%, 100%). Tryptase concentration in the nasal lavage and a relative eosinophil number were significantly higher in allergic than non-allergic patients. No correlation was found between the relative number of eosinophils and degree of nasal hyperreactivity. Likewise no correlation was found between any of the cellular markers and level of nasal hyperreactivity, and no difference in marker levels between the groups. The correlation between ECP and MPO in nasal lavage was significant. Since there is no correlation between inflammatory cell activation and the degree of nasal hyperreactivity, it may be concluded that neural reflexes leading to nasal congestion after non-isotonic aerosol inhalation are not dependent on the level of inflammation measured bythe activation of granulocytes and mastocytes.

Rhinitis - allergic; non-allergic; nasal hyperreactivity

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

67-x.

2008.

objavljeno

Podaci o matičnoj publikaciji

Abstract book of the 7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN)

Scadding, Glenis ; Kalogjera, Livije

Zagreb:

Podaci o skupu

7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN)

predavanje

13.11.2008-15.11.2008

Dubrovnik, Hrvatska

Povezanost rada

Kliničke medicinske znanosti