Interaction of salicylic acid with calcite (CROSBI ID 548855)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Ukrainczyk, Marko ; Kralj, Damir
engleski
Interaction of salicylic acid with calcite
In recent years much attention have been devoted to the development of various drug delivery systems for controlled introduction and/or release of active organic substances in living organisms and tissues. Their application can also enhance drug stability and bioavailability or even target the drug to the specified cell or tissue as well. Although, the organic drug delivery systems are regularly used (e.g. liposomes, micelles etc.), some inorganic carriers have been recently developed and proposed for modulating drug delivery. In particular, calcium carbonate has potential use as mineral carrier of pharmaceutical substances due to its low cost, nontoxic properties and biocompatibility. The purpose of this work is to investigate the mechanism and extent of adsorption of salicylic acid, non-steroidal anti-inflammatory drug used as organic model molecule, on the calcite crystals of either, rhombohedral or scalenohedral morphology. The calcite crystal seed of rhombohedral and scalenohedral morphology have been prepared in precipitation system Ca(OH)2(s) – H2O(l) – CO2(g), which enables the preparation of high quantity of pure and well defined precipitate. Samples were characterized by means of FT-IR spectroscopy, scanning electron microscopy and surface area analyzer by the BET method of nitrogen adsorption. The adsorption of salicylic acid on calcite was studied using batch adsorption technique by means of UV spectroscopy and acoustic spectroscopy. In order to study the salicylic acid and calcite surface interactions, we investigate the effect of salicylic acid on the kinetics of calcite seed crystal growth. The precipitation process was followed by recording pH as a function of time. It was found that the extent of adsorption was higher at lower pH, which was explained to be a consequence of lower fraction of CO32- in solution at such conditions. The carbonate ions block the active sites on the calcite surface, thus competing with salicylate ions for the calcium sites on the calcite surface. However, the adsorption was found to be more pronounced on rhombohedral than on scalenohedral calcite, as a consequence of their different surface structure.
Precipitation; adsorption; calcite; salicylic acid
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Podaci o prilogu
129-129.
2009.
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objavljeno
Podaci o matičnoj publikaciji
International School of Crystallization Abstract Book
Juan Manuel Garcia Ruiz
Granada: Laboratorio de Estudios Cristalograficos
Podaci o skupu
International School of Crystallization: Foods, Drugs and Agrochemicals
poster
25.05.2009-29.05.2009
Granada, Španjolska