Serotonin transporter gene polymorphisms in Crohn's disease patients (CROSBI ID 548799)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Grubelić Ravić, Katja ; Čuković Čavka, Silvija ; Anzulović, Dora ; Brinar, Marko ; Krznarić, Željko ; Sertić, Jadranka ; Božina, Nada ; Rojnić Kuzman, Martina ; Vucelić, Boris
engleski
Serotonin transporter gene polymorphisms in Crohn's disease patients
Serotonin (5-HT) is an important factor in gut function, playing key roles in intestinal peristalsis, secretion, vasodilatation and sensory signalling. The serotoninselective reuptake transporter protein (SERT) terminates the action of 5-HT. Human SERT is encoded by a single gene on chromosome 17q11 ; two important polymorphic sites in the SERT gene are: variable number tandem repeats in the gene’ s second intron (SERTin2), and an insertion/deletion in the promoter region (SERTPR). Consistent with the effects of 5-HT in the gut, SERT polymorphisms could potentially be involved in the development of IBD. The aim of this study was to evaluate the possible role of SERT polymorphisms in pathogenesis of CD.
serotonin transporter gene polymorphisms; Crohn disease
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Podaci o prilogu
2009.
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objavljeno
Podaci o matičnoj publikaciji
Journal of CrohnNULLs and colitis
Hamburg:
1873-9946
Podaci o skupu
4th Congress of ECCO
poster
05.02.2009-07.02.2009
Hamburg, Njemačka