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Pregled bibliografske jedinice broj: 39831

The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues.


Šprem, Marina; Babić, Damir; Abramić, Marija; Miličić, Duško; Vrhovec, Ivan; Škrk, Janez; Osmak, Maja
The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues. // Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB 2000. Knjiga sažetaka. / Flögel, Mirna (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet, 2000. str. 66-66 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 39831 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues.

Autori
Šprem, Marina ; Babić, Damir ; Abramić, Marija ; Miličić, Duško ; Vrhovec, Ivan ; Škrk, Janez ; Osmak, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB 2000. Knjiga sažetaka. / Flögel, Mirna - Zagreb : Farmaceutsko-biokemijski fakultet, 2000, 66-66

Skup
Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB 2000. (Silver Jubilee Meeting of the Croatian Biochemical Society)

Mjesto i datum
Zagreb, Hrvatska, 13.-15. 10. 2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
cathepsin D; plasminogen activator inhibitor; ovarian tissue; tumor

Sažetak
Among gynaecological malignancies, ovarian cancer has been the major cause of death, because it is usually presented in advances clinical stage, with extensive intraabdominal metastasis and the unavoidable development of resistance to chemotherapy. Research continues along several fronts in an attempt to improve the diagnosis and prognosis of women with ovarian cancer. The aim of the present study was to determine the concentrations of cathepsin D (Cath D) and plasminogen activator inhibitor type 1 (PAI-1) in normal, benign and malignant ovarian tissues, and to asses relationship between Cath D and PAI-1 content and some clinical and pathohistological parameters. Cath D and PAI-1, two tumor markers for invasion and metastasis, were analysed in 35 samples: 10 normal ovarii, 10 benign, 10 primary malignant and 5 metastatic ovarian tumors. Their levels were quantified using immunoradiometric ELSA-Cath D assay and commercial IMUBINDR ELISA immunoassay, respectively. The concentrations of Cath D were significantly higher in malignant (32.89ą14.26 pmol/mg protein ) and metastatic (31.42 ą10.24 pmol/mg protein), than in normal (13.68ą4.03 pmol/mg protein) and benign (17.89ą13.13 pmol/mg protein) ovarian tissues. There was no statistical differences in the concentrations of PAI-1 between normal, benign , malignant and metastatic tumor specimens. The concentration of Cath D as well as PAI-1 did not correlate to age of patients, menopausal status, parity, GOG risk group, clinical stage or pathohistological grading. In conclusion, concentrations of Cath D ( but not PAI-1) were significantly increased in malignant and metastatic ovarian tumor tissues when compared to normal and benign ovarian tumor samples; they were independent from pathohistological and clinical parameters.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekti:
00980705
00981008

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Šprem, Marina; Babić, Damir; Abramić, Marija; Miličić, Duško; Vrhovec, Ivan; Škrk, Janez; Osmak, Maja
The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues. // Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB 2000. Knjiga sažetaka. / Flögel, Mirna (ur.).
Zagreb: Farmaceutsko-biokemijski fakultet, 2000. str. 66-66 (poster, domaća recenzija, sažetak, znanstveni)
Šprem, M., Babić, D., Abramić, M., Miličić, D., Vrhovec, I., Škrk, J. & Osmak, M. (2000) The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues.. U: Flögel, M. (ur.)Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB 2000. Knjiga sažetaka..
@article{article, editor = {Fl\"{o}gel, M.}, year = {2000}, pages = {66-66}, keywords = {cathepsin D, plasminogen activator inhibitor, ovarian tissue, tumor}, title = {The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues.}, keyword = {cathepsin D, plasminogen activator inhibitor, ovarian tissue, tumor}, publisher = {Farmaceutsko-biokemijski fakultet}, publisherplace = {Zagreb, Hrvatska} }
@article{article, editor = {Fl\"{o}gel, M.}, year = {2000}, pages = {66-66}, keywords = {cathepsin D, plasminogen activator inhibitor, ovarian tissue, tumor}, title = {The level of cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues.}, keyword = {cathepsin D, plasminogen activator inhibitor, ovarian tissue, tumor}, publisher = {Farmaceutsko-biokemijski fakultet}, publisherplace = {Zagreb, Hrvatska} }




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