engleski

Neuromagnetic insight into cortical dynamics: Simulation and empirical studies

Neuroplasticity and in particular cognitive neurodynamics of the developing human brain are challenging and largely unknown despite significant advances in the functional and structural imaging of the human brain. Such information is not readily available even with the invasive approaches since they are typically performed on epileptic patients providing pathology related distortions. The relevance of the extraction of the neuronal activation timecourse comes from evidences that dysfunction and age related changes are often related to the interaction pathways. MEG represents a direct and real-time measure of neuronal activity and offers monitoring of the spontaneous and evoked brain responses with a millisecond resolution parallel only to the electroencephalography (EEG). In addition, it offers the possibility of identifying the underlying neuronal substrate and tracking when, where, and how the activity changes over time without knowledge of a detailed conductive geometry profile. Neuromagnetic source dynamics accuracy, however, is model and inverse procedure dependent. The results of experimental and numerical simulation studies will be presented on the spatio-temporal source discrimination as well as location and timecourse estimation accuracy of the activated cortical sources. Since functional neuroanatomy differs between individuals we will provide empirical and simulation evidences in favor of a within subject analysis in particular in the light of a lifetime neuroplasticity of the brain both in health and disease.

cognitive neurodynamics; neuroplasticity; spatio-temporal source discrimination; MEG

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